A Systematic Study of the Antibacterial Activity of Basidiomycota Crude Extracts

The excessive consumption of antibiotics in clinical, veterinary and agricultural fields has resulted in tremendous flow of antibiotics into the environment. This has led to enormous selective pressures driving the evolution of antimicrobial resistance genes in pathogenic and commensal bacteria. In...

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Autores principales:	Marco Clericuzio, Mattia Bivona, Elisa Gamalero, Elisa Bona, Giorgia Novello, Nadia Massa, Francesco Dovana, Emilio Marengo, Elisa Robotti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Cortinarius</i> <i>Mycena</i> <i>Ramaria</i> antifungal activity antibacterial activity <i>Candida albicans</i> Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/6d1fc37e2a47425aba031f0f66b6458f
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spelling	oai:doaj.org-article:6d1fc37e2a47425aba031f0f66b6458f2021-11-25T16:25:12ZA Systematic Study of the Antibacterial Activity of Basidiomycota Crude Extracts10.3390/antibiotics101114242079-6382https://doaj.org/article/6d1fc37e2a47425aba031f0f66b6458f2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1424https://doaj.org/toc/2079-6382The excessive consumption of antibiotics in clinical, veterinary and agricultural fields has resulted in tremendous flow of antibiotics into the environment. This has led to enormous selective pressures driving the evolution of antimicrobial resistance genes in pathogenic and commensal bacteria. In this context, the World Health Organization (WHO) has promoted research aiming to develop medical features using natural products that are often competitive with synthetic drugs in clinical performance. Fungi are considered an important source of bioactive molecules, often effective against other fungi and/or bacteria, and thus are potential candidates in the search of new antibiotics. Fruiting bodies of sixteen different fungal species of Basidiomycota were collected in the Italian Alps. The identification of fungal species was performed through Internal Transcribed Spacer (ITS) sequencing. Most species belong to genera <i>Cortinarius</i>, <i>Mycena</i> and <i>Ramaria</i>, whose metabolite contents has been scarcely investigated so far. The crude extracts obtained from the above mushrooms were tested for their inhibition activity against five human pathogens: <i>Candida albicans</i> ATCC 14053, <i>C. glabrata</i> ATCC 15126, <i>Staphylococcus aureus</i> NCTC 6571, <i>Pseudomonas aeruginosa</i> ATCC 27853 and <i>Klebsiella pneumoniae</i> ATCC 13883. Twelve crude extracts showed activity against <i>P. aeruginosa</i> ATCC 27853. Highest activity was shown by some <i>Cortinarius</i> species, as <i>C. nanceiensis</i>.Marco ClericuzioMattia BivonaElisa GamaleroElisa BonaGiorgia NovelloNadia MassaFrancesco DovanaEmilio MarengoElisa RobottiMDPI AGarticle<i>Cortinarius</i><i>Mycena</i><i>Ramaria</i>antifungal activityantibacterial activity<i>Candida albicans</i>Therapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1424, p 1424 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Cortinarius</i> <i>Mycena</i> <i>Ramaria</i> antifungal activity antibacterial activity <i>Candida albicans</i> Therapeutics. Pharmacology RM1-950
spellingShingle	<i>Cortinarius</i> <i>Mycena</i> <i>Ramaria</i> antifungal activity antibacterial activity <i>Candida albicans</i> Therapeutics. Pharmacology RM1-950 Marco Clericuzio Mattia Bivona Elisa Gamalero Elisa Bona Giorgia Novello Nadia Massa Francesco Dovana Emilio Marengo Elisa Robotti A Systematic Study of the Antibacterial Activity of Basidiomycota Crude Extracts
description	The excessive consumption of antibiotics in clinical, veterinary and agricultural fields has resulted in tremendous flow of antibiotics into the environment. This has led to enormous selective pressures driving the evolution of antimicrobial resistance genes in pathogenic and commensal bacteria. In this context, the World Health Organization (WHO) has promoted research aiming to develop medical features using natural products that are often competitive with synthetic drugs in clinical performance. Fungi are considered an important source of bioactive molecules, often effective against other fungi and/or bacteria, and thus are potential candidates in the search of new antibiotics. Fruiting bodies of sixteen different fungal species of Basidiomycota were collected in the Italian Alps. The identification of fungal species was performed through Internal Transcribed Spacer (ITS) sequencing. Most species belong to genera <i>Cortinarius</i>, <i>Mycena</i> and <i>Ramaria</i>, whose metabolite contents has been scarcely investigated so far. The crude extracts obtained from the above mushrooms were tested for their inhibition activity against five human pathogens: <i>Candida albicans</i> ATCC 14053, <i>C. glabrata</i> ATCC 15126, <i>Staphylococcus aureus</i> NCTC 6571, <i>Pseudomonas aeruginosa</i> ATCC 27853 and <i>Klebsiella pneumoniae</i> ATCC 13883. Twelve crude extracts showed activity against <i>P. aeruginosa</i> ATCC 27853. Highest activity was shown by some <i>Cortinarius</i> species, as <i>C. nanceiensis</i>.
format	article
author	Marco Clericuzio Mattia Bivona Elisa Gamalero Elisa Bona Giorgia Novello Nadia Massa Francesco Dovana Emilio Marengo Elisa Robotti
author_facet	Marco Clericuzio Mattia Bivona Elisa Gamalero Elisa Bona Giorgia Novello Nadia Massa Francesco Dovana Emilio Marengo Elisa Robotti
author_sort	Marco Clericuzio
title	A Systematic Study of the Antibacterial Activity of Basidiomycota Crude Extracts
title_short	A Systematic Study of the Antibacterial Activity of Basidiomycota Crude Extracts
title_full	A Systematic Study of the Antibacterial Activity of Basidiomycota Crude Extracts
title_fullStr	A Systematic Study of the Antibacterial Activity of Basidiomycota Crude Extracts
title_full_unstemmed	A Systematic Study of the Antibacterial Activity of Basidiomycota Crude Extracts
title_sort	systematic study of the antibacterial activity of basidiomycota crude extracts
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6d1fc37e2a47425aba031f0f66b6458f
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A Systematic Study of the Antibacterial Activity of Basidiomycota Crude Extracts

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