Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence

Jin-Xiu Pan et al. report that an osteoblast-specific expression of Swedish mutant amyloid precursor protein (APPswe) induces ER stress-driven senescence, leading to systemic inflammation and inflammation in the cortex that drives behavioral changes. The results demonstrate a previously unrecognized...

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Autores principales:	Jin-Xiu Pan, Dong Sun, Daehoon Lee, Lei Xiong, Xiao Ren, Hao-han Guo, Ling-Ling Yao, Yuyi Lu, Caroline Jung, Wen-Cheng Xiong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6d1fdf67c02a4431b8721cdb4dab2785
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spelling	oai:doaj.org-article:6d1fdf67c02a4431b8721cdb4dab27852021-11-28T12:10:17ZOsteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence10.1038/s42003-021-02843-22399-3642https://doaj.org/article/6d1fdf67c02a4431b8721cdb4dab27852021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02843-2https://doaj.org/toc/2399-3642Jin-Xiu Pan et al. report that an osteoblast-specific expression of Swedish mutant amyloid precursor protein (APPswe) induces ER stress-driven senescence, leading to systemic inflammation and inflammation in the cortex that drives behavioral changes. The results demonstrate a previously unrecognized function of osteoblastic APPswe to brain axis in AD development.Jin-Xiu PanDong SunDaehoon LeeLei XiongXiao RenHao-han GuoLing-Ling YaoYuyi LuCaroline JungWen-Cheng XiongNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jin-Xiu Pan Dong Sun Daehoon Lee Lei Xiong Xiao Ren Hao-han Guo Ling-Ling Yao Yuyi Lu Caroline Jung Wen-Cheng Xiong Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
description	Jin-Xiu Pan et al. report that an osteoblast-specific expression of Swedish mutant amyloid precursor protein (APPswe) induces ER stress-driven senescence, leading to systemic inflammation and inflammation in the cortex that drives behavioral changes. The results demonstrate a previously unrecognized function of osteoblastic APPswe to brain axis in AD development.
format	article
author	Jin-Xiu Pan Dong Sun Daehoon Lee Lei Xiong Xiao Ren Hao-han Guo Ling-Ling Yao Yuyi Lu Caroline Jung Wen-Cheng Xiong
author_facet	Jin-Xiu Pan Dong Sun Daehoon Lee Lei Xiong Xiao Ren Hao-han Guo Ling-Ling Yao Yuyi Lu Caroline Jung Wen-Cheng Xiong
author_sort	Jin-Xiu Pan
title	Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
title_short	Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
title_full	Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
title_fullStr	Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
title_full_unstemmed	Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
title_sort	osteoblastic swedish mutant app expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6d1fdf67c02a4431b8721cdb4dab2785
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Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence

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