Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
Jin-Xiu Pan et al. report that an osteoblast-specific expression of Swedish mutant amyloid precursor protein (APPswe) induces ER stress-driven senescence, leading to systemic inflammation and inflammation in the cortex that drives behavioral changes. The results demonstrate a previously unrecognized...
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Autores principales: | Jin-Xiu Pan, Dong Sun, Daehoon Lee, Lei Xiong, Xiao Ren, Hao-han Guo, Ling-Ling Yao, Yuyi Lu, Caroline Jung, Wen-Cheng Xiong |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/6d1fdf67c02a4431b8721cdb4dab2785 |
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