Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase

Histone phosphorylation is a ubiquitous post-translational modification. Here the authors present a programmable chromatin kinase, dCas9-dMSK1, that enables controlled histone phosphorylation and specific gene activation.

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Autores principales:	Jing Li, Barun Mahata, Mario Escobar, Jacob Goell, Kaiyuan Wang, Pranav Khemka, Isaac B. Hilton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d21162ee2d44cb2a82ad45c7417447d
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spelling	oai:doaj.org-article:6d21162ee2d44cb2a82ad45c7417447d2021-12-02T14:26:44ZProgrammable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase10.1038/s41467-021-21188-22041-1723https://doaj.org/article/6d21162ee2d44cb2a82ad45c7417447d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21188-2https://doaj.org/toc/2041-1723Histone phosphorylation is a ubiquitous post-translational modification. Here the authors present a programmable chromatin kinase, dCas9-dMSK1, that enables controlled histone phosphorylation and specific gene activation.Jing LiBarun MahataMario EscobarJacob GoellKaiyuan WangPranav KhemkaIsaac B. HiltonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jing Li Barun Mahata Mario Escobar Jacob Goell Kaiyuan Wang Pranav Khemka Isaac B. Hilton Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase
description	Histone phosphorylation is a ubiquitous post-translational modification. Here the authors present a programmable chromatin kinase, dCas9-dMSK1, that enables controlled histone phosphorylation and specific gene activation.
format	article
author	Jing Li Barun Mahata Mario Escobar Jacob Goell Kaiyuan Wang Pranav Khemka Isaac B. Hilton
author_facet	Jing Li Barun Mahata Mario Escobar Jacob Goell Kaiyuan Wang Pranav Khemka Isaac B. Hilton
author_sort	Jing Li
title	Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase
title_short	Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase
title_full	Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase
title_fullStr	Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase
title_full_unstemmed	Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase
title_sort	programmable human histone phosphorylation and gene activation using a crispr/cas9-based chromatin kinase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6d21162ee2d44cb2a82ad45c7417447d
work_keys_str_mv	AT jingli programmablehumanhistonephosphorylationandgeneactivationusingacrisprcas9basedchromatinkinase AT barunmahata programmablehumanhistonephosphorylationandgeneactivationusingacrisprcas9basedchromatinkinase AT marioescobar programmablehumanhistonephosphorylationandgeneactivationusingacrisprcas9basedchromatinkinase AT jacobgoell programmablehumanhistonephosphorylationandgeneactivationusingacrisprcas9basedchromatinkinase AT kaiyuanwang programmablehumanhistonephosphorylationandgeneactivationusingacrisprcas9basedchromatinkinase AT pranavkhemka programmablehumanhistonephosphorylationandgeneactivationusingacrisprcas9basedchromatinkinase AT isaacbhilton programmablehumanhistonephosphorylationandgeneactivationusingacrisprcas9basedchromatinkinase
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Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase

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