Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

Dietary changes can impact the microbial constitution of the gastrointestinal tract and modulate the local immune response. Here, the authors show supplementation using lysates of Methylococcus capsulatus Bath result in changes to the microbiota, modulate Treg populations and metabolic read outs in...

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Autores principales:	Benjamin A. H. Jensen, Jacob B. Holm, Ida S. Larsen, Nicole von Burg, Stefanie Derer, Si B. Sonne, Simone I. Pærregaard, Mads V. Damgaard, Stine A. Indrelid, Aymeric Rivollier, Anne-Laure Agrinier, Karolina Sulek, Yke J. Arnoldussen, Even Fjære, André Marette, Inga L. Angell, Knut Rudi, Jonas T. Treebak, Lise Madsen, Caroline Piercey Åkesson, William Agace, Christian Sina, Charlotte R. Kleiveland, Karsten Kristiansen, Tor E. Lea
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d241f5cd4dd4d7db29da98719e9cff1
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spelling	oai:doaj.org-article:6d241f5cd4dd4d7db29da98719e9cff12021-12-02T12:11:39ZLysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism10.1038/s41467-021-21408-92041-1723https://doaj.org/article/6d241f5cd4dd4d7db29da98719e9cff12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21408-9https://doaj.org/toc/2041-1723Dietary changes can impact the microbial constitution of the gastrointestinal tract and modulate the local immune response. Here, the authors show supplementation using lysates of Methylococcus capsulatus Bath result in changes to the microbiota, modulate Treg populations and metabolic read outs in a dietary control murine model.Benjamin A. H. JensenJacob B. HolmIda S. LarsenNicole von BurgStefanie DererSi B. SonneSimone I. PærregaardMads V. DamgaardStine A. IndrelidAymeric RivollierAnne-Laure AgrinierKarolina SulekYke J. ArnoldussenEven FjæreAndré MaretteInga L. AngellKnut RudiJonas T. TreebakLise MadsenCaroline Piercey ÅkessonWilliam AgaceChristian SinaCharlotte R. KleivelandKarsten KristiansenTor E. LeaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin A. H. Jensen Jacob B. Holm Ida S. Larsen Nicole von Burg Stefanie Derer Si B. Sonne Simone I. Pærregaard Mads V. Damgaard Stine A. Indrelid Aymeric Rivollier Anne-Laure Agrinier Karolina Sulek Yke J. Arnoldussen Even Fjære André Marette Inga L. Angell Knut Rudi Jonas T. Treebak Lise Madsen Caroline Piercey Åkesson William Agace Christian Sina Charlotte R. Kleiveland Karsten Kristiansen Tor E. Lea Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism
description	Dietary changes can impact the microbial constitution of the gastrointestinal tract and modulate the local immune response. Here, the authors show supplementation using lysates of Methylococcus capsulatus Bath result in changes to the microbiota, modulate Treg populations and metabolic read outs in a dietary control murine model.
format	article
author	Benjamin A. H. Jensen Jacob B. Holm Ida S. Larsen Nicole von Burg Stefanie Derer Si B. Sonne Simone I. Pærregaard Mads V. Damgaard Stine A. Indrelid Aymeric Rivollier Anne-Laure Agrinier Karolina Sulek Yke J. Arnoldussen Even Fjære André Marette Inga L. Angell Knut Rudi Jonas T. Treebak Lise Madsen Caroline Piercey Åkesson William Agace Christian Sina Charlotte R. Kleiveland Karsten Kristiansen Tor E. Lea
author_facet	Benjamin A. H. Jensen Jacob B. Holm Ida S. Larsen Nicole von Burg Stefanie Derer Si B. Sonne Simone I. Pærregaard Mads V. Damgaard Stine A. Indrelid Aymeric Rivollier Anne-Laure Agrinier Karolina Sulek Yke J. Arnoldussen Even Fjære André Marette Inga L. Angell Knut Rudi Jonas T. Treebak Lise Madsen Caroline Piercey Åkesson William Agace Christian Sina Charlotte R. Kleiveland Karsten Kristiansen Tor E. Lea
author_sort	Benjamin A. H. Jensen
title	Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism
title_short	Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism
title_full	Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism
title_fullStr	Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism
title_full_unstemmed	Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism
title_sort	lysates of methylococcus capsulatus bath induce a lean-like microbiota, intestinal foxp3+rorγt+il-17+ tregs and improve metabolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6d241f5cd4dd4d7db29da98719e9cff1
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Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

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