Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core

Pei et al. explore the mechanism underlying growth of mutant huntingtin inclusions in yeast cells and show that growth occurs through random collision and incorporation of mutant huntingtin aggregates into a phase-separated condensate. They show that there is a small inner core which is structurally...

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Autores principales:	Sen Pei, Theresa C. Swayne, Jeffrey F. Morris, Lesley Emtage
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6d251d73fa644cdba7772c0eaea333ec
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spelling	oai:doaj.org-article:6d251d73fa644cdba7772c0eaea333ec2021-12-02T17:08:22ZThreshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core10.1038/s42003-021-02460-z2399-3642https://doaj.org/article/6d251d73fa644cdba7772c0eaea333ec2021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02460-zhttps://doaj.org/toc/2399-3642Pei et al. explore the mechanism underlying growth of mutant huntingtin inclusions in yeast cells and show that growth occurs through random collision and incorporation of mutant huntingtin aggregates into a phase-separated condensate. They show that there is a small inner core which is structurally distinct, and may serve to nucleate the inclusion.Sen PeiTheresa C. SwayneJeffrey F. MorrisLesley EmtageNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sen Pei Theresa C. Swayne Jeffrey F. Morris Lesley Emtage Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core
description	Pei et al. explore the mechanism underlying growth of mutant huntingtin inclusions in yeast cells and show that growth occurs through random collision and incorporation of mutant huntingtin aggregates into a phase-separated condensate. They show that there is a small inner core which is structurally distinct, and may serve to nucleate the inclusion.
format	article
author	Sen Pei Theresa C. Swayne Jeffrey F. Morris Lesley Emtage
author_facet	Sen Pei Theresa C. Swayne Jeffrey F. Morris Lesley Emtage
author_sort	Sen Pei
title	Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core
title_short	Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core
title_full	Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core
title_fullStr	Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core
title_full_unstemmed	Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core
title_sort	threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6d251d73fa644cdba7772c0eaea333ec
work_keys_str_mv	AT senpei thresholdconcentrationandrandomcollisiondeterminethegrowthofthehuntingtininclusionfromastablecore AT theresacswayne thresholdconcentrationandrandomcollisiondeterminethegrowthofthehuntingtininclusionfromastablecore AT jeffreyfmorris thresholdconcentrationandrandomcollisiondeterminethegrowthofthehuntingtininclusionfromastablecore AT lesleyemtage thresholdconcentrationandrandomcollisiondeterminethegrowthofthehuntingtininclusionfromastablecore
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Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core

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