Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148
Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.
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Nature Portfolio
2017
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oai:doaj.org-article:6d29a2104a5544a480a010afb3a1a2022021-12-02T15:38:48ZFunctional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF14810.1038/ncomms150342041-1723https://doaj.org/article/6d29a2104a5544a480a010afb3a1a2022017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15034https://doaj.org/toc/2041-1723Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.Jun FangJinping JiaMatthew MakowskiMai XuZhaoming WangTongwu ZhangJason W. HoskinsJiyeon ChoiYounghun HanMingfeng ZhangJanelle ThomasMichael KovacsIrene CollinsMarta DzyadykAbbey ThompsonMaura O'NeillSudipto DasQi LanRoelof KosterPanScan ConsortiumTRICL ConsortiumGenoMEL ConsortiumRachael S. Stolzenberg-SolomonPeter KraftBrian M. WolpinPascal W. T. C. JansenSara OlsonKatherine A. McGlynnPeter A. KanetskyNilanjan ChatterjeeJennifer H. BarrettAlison M. DunningJohn C. TaylorJulia A. Newton-BishopD. Timothy BishopThorkell AndressonGloria M. PetersenChristopher I. AmosMark M. IlesKatherine L. NathansonMaria Teresa LandiMichiel VermeulenKevin M. BrownLaufey T. AmundadottirNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
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DOAJ |
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Science Q |
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Science Q Jun Fang Jinping Jia Matthew Makowski Mai Xu Zhaoming Wang Tongwu Zhang Jason W. Hoskins Jiyeon Choi Younghun Han Mingfeng Zhang Janelle Thomas Michael Kovacs Irene Collins Marta Dzyadyk Abbey Thompson Maura O'Neill Sudipto Das Qi Lan Roelof Koster PanScan Consortium TRICL Consortium GenoMEL Consortium Rachael S. Stolzenberg-Solomon Peter Kraft Brian M. Wolpin Pascal W. T. C. Jansen Sara Olson Katherine A. McGlynn Peter A. Kanetsky Nilanjan Chatterjee Jennifer H. Barrett Alison M. Dunning John C. Taylor Julia A. Newton-Bishop D. Timothy Bishop Thorkell Andresson Gloria M. Petersen Christopher I. Amos Mark M. Iles Katherine L. Nathanson Maria Teresa Landi Michiel Vermeulen Kevin M. Brown Laufey T. Amundadottir Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148 |
| description |
Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148. |
| format |
article |
| author |
Jun Fang Jinping Jia Matthew Makowski Mai Xu Zhaoming Wang Tongwu Zhang Jason W. Hoskins Jiyeon Choi Younghun Han Mingfeng Zhang Janelle Thomas Michael Kovacs Irene Collins Marta Dzyadyk Abbey Thompson Maura O'Neill Sudipto Das Qi Lan Roelof Koster PanScan Consortium TRICL Consortium GenoMEL Consortium Rachael S. Stolzenberg-Solomon Peter Kraft Brian M. Wolpin Pascal W. T. C. Jansen Sara Olson Katherine A. McGlynn Peter A. Kanetsky Nilanjan Chatterjee Jennifer H. Barrett Alison M. Dunning John C. Taylor Julia A. Newton-Bishop D. Timothy Bishop Thorkell Andresson Gloria M. Petersen Christopher I. Amos Mark M. Iles Katherine L. Nathanson Maria Teresa Landi Michiel Vermeulen Kevin M. Brown Laufey T. Amundadottir |
| author_facet |
Jun Fang Jinping Jia Matthew Makowski Mai Xu Zhaoming Wang Tongwu Zhang Jason W. Hoskins Jiyeon Choi Younghun Han Mingfeng Zhang Janelle Thomas Michael Kovacs Irene Collins Marta Dzyadyk Abbey Thompson Maura O'Neill Sudipto Das Qi Lan Roelof Koster PanScan Consortium TRICL Consortium GenoMEL Consortium Rachael S. Stolzenberg-Solomon Peter Kraft Brian M. Wolpin Pascal W. T. C. Jansen Sara Olson Katherine A. McGlynn Peter A. Kanetsky Nilanjan Chatterjee Jennifer H. Barrett Alison M. Dunning John C. Taylor Julia A. Newton-Bishop D. Timothy Bishop Thorkell Andresson Gloria M. Petersen Christopher I. Amos Mark M. Iles Katherine L. Nathanson Maria Teresa Landi Michiel Vermeulen Kevin M. Brown Laufey T. Amundadottir |
| author_sort |
Jun Fang |
| title |
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148 |
| title_short |
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148 |
| title_full |
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148 |
| title_fullStr |
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148 |
| title_full_unstemmed |
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148 |
| title_sort |
functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of tert by znf148 |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/6d29a2104a5544a480a010afb3a1a202 |
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