Decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype

Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an early onset and a strong genetic origin. Unaffected relatives may present similar but subthreshold characteristics of ASD. This broader autism phenotype is especially prevalent in the parents of individuals with ASD, su...

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Autores principales:	Kyung-min An, Takashi Ikeda, Tetsu Hirosawa, Ken Yaoi, Yuko Yoshimura, Chiaki Hasegawa, Sanae Tanaka, Daisuke N. Saito, Mitsuru Kikuchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d2b8dd13e9947d4b95e38909b33c97c
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spelling	oai:doaj.org-article:6d2b8dd13e9947d4b95e38909b33c97c2021-12-02T17:02:21ZDecreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype10.1038/s41598-021-89393-z2045-2322https://doaj.org/article/6d2b8dd13e9947d4b95e38909b33c97c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89393-zhttps://doaj.org/toc/2045-2322Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an early onset and a strong genetic origin. Unaffected relatives may present similar but subthreshold characteristics of ASD. This broader autism phenotype is especially prevalent in the parents of individuals with ASD, suggesting that it has heritable factors. Although previous studies have demonstrated brain morphometry differences in ASD, they are poorly understood in parents of individuals with ASD. Here, we estimated grey matter volume in 45 mothers of children with ASD (mASD) and 46 age-, sex-, and handedness-matched controls using whole-brain voxel-based morphometry analysis. The mASD group had smaller grey matter volume in the right middle temporal gyrus, temporoparietal junction, cerebellum, and parahippocampal gyrus compared with the control group. Furthermore, we analysed the correlations of these brain volumes with ASD behavioural characteristics using autism spectrum quotient (AQ) and systemizing quotient (SQ) scores, which measure general autistic traits and the drive to systemize. Smaller volumes in the middle temporal gyrus and temporoparietal junction correlated with higher SQ scores, and smaller volumes in the cerebellum and parahippocampal gyrus correlated with higher AQ scores. Our findings suggest that atypical grey matter volumes in mASD may represent one of the neurostructural endophenotypes of ASD.Kyung-min AnTakashi IkedaTetsu HirosawaKen YaoiYuko YoshimuraChiaki HasegawaSanae TanakaDaisuke N. SaitoMitsuru KikuchiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyung-min An Takashi Ikeda Tetsu Hirosawa Ken Yaoi Yuko Yoshimura Chiaki Hasegawa Sanae Tanaka Daisuke N. Saito Mitsuru Kikuchi Decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype
description	Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an early onset and a strong genetic origin. Unaffected relatives may present similar but subthreshold characteristics of ASD. This broader autism phenotype is especially prevalent in the parents of individuals with ASD, suggesting that it has heritable factors. Although previous studies have demonstrated brain morphometry differences in ASD, they are poorly understood in parents of individuals with ASD. Here, we estimated grey matter volume in 45 mothers of children with ASD (mASD) and 46 age-, sex-, and handedness-matched controls using whole-brain voxel-based morphometry analysis. The mASD group had smaller grey matter volume in the right middle temporal gyrus, temporoparietal junction, cerebellum, and parahippocampal gyrus compared with the control group. Furthermore, we analysed the correlations of these brain volumes with ASD behavioural characteristics using autism spectrum quotient (AQ) and systemizing quotient (SQ) scores, which measure general autistic traits and the drive to systemize. Smaller volumes in the middle temporal gyrus and temporoparietal junction correlated with higher SQ scores, and smaller volumes in the cerebellum and parahippocampal gyrus correlated with higher AQ scores. Our findings suggest that atypical grey matter volumes in mASD may represent one of the neurostructural endophenotypes of ASD.
format	article
author	Kyung-min An Takashi Ikeda Tetsu Hirosawa Ken Yaoi Yuko Yoshimura Chiaki Hasegawa Sanae Tanaka Daisuke N. Saito Mitsuru Kikuchi
author_facet	Kyung-min An Takashi Ikeda Tetsu Hirosawa Ken Yaoi Yuko Yoshimura Chiaki Hasegawa Sanae Tanaka Daisuke N. Saito Mitsuru Kikuchi
author_sort	Kyung-min An
title	Decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype
title_short	Decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype
title_full	Decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype
title_fullStr	Decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype
title_full_unstemmed	Decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype
title_sort	decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6d2b8dd13e9947d4b95e38909b33c97c
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Decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype

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