Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999–2006

Loss of muscle mass and waning in muscle strength are common in older adults, and inflammation may play a key role in pathogenesis. This study aimed to examine associations of C-reactive protein (CRP) and systemic immune-inflammation index (SII) with sarcopenia and sarcopenic obesity in older adults...

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Autores principales:	Shama D. Karanth, Caretia Washington, Ting-Yuan D. Cheng, Daohong Zhou, Christiaan Leeuwenburgh, Dejana Braithwaite, Dongyu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sarcopenia sarcopenic obesity inflammation epidemiology Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/6d2ce6ecf543453e9776c034634ebc91
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spelling	oai:doaj.org-article:6d2ce6ecf543453e9776c034634ebc912021-11-25T18:35:36ZInflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999–200610.3390/nu131139572072-6643https://doaj.org/article/6d2ce6ecf543453e9776c034634ebc912021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3957https://doaj.org/toc/2072-6643Loss of muscle mass and waning in muscle strength are common in older adults, and inflammation may play a key role in pathogenesis. This study aimed to examine associations of C-reactive protein (CRP) and systemic immune-inflammation index (SII) with sarcopenia and sarcopenic obesity in older adults with chronic comorbidities. Cross-sectional data from the National Health and Nutrition Examination Survey (1999–2006) were obtained for participants aged ≥60 years. Sarcopenia was defined by a lean mass and body height (males < 7.26 kg/m<sup>2</sup>, females < 5.45 kg/m<sup>2</sup>). Sarcopenic obesity was defined by the concurrent presence of sarcopenia and obesity (defined by relative fat mass). Logistic regression was used to assess the associations of CRP and SII with sarcopenia and sarcopenic obesity. The dose–response relationship was examined via restricted cubic splines. Of the participants (<i>n</i> = 2483), 23.1% (<i>n</i> = 574) and 7.7% (<i>n</i> = 190) had sarcopenia and sarcopenic obesity, respectively. The multivariable logistic regression models suggested a positive association of SII with sarcopenia and sarcopenic obesity, but a positive statistically significant association was not consistently observed for CRP. Dose–response curves suggested similar association patterns for these biomarkers. In clinical practice, measures to prevent sarcopenia and sarcopenic obesity are needed for older vulnerable people with high systemic inflammation.Shama D. KaranthCaretia WashingtonTing-Yuan D. ChengDaohong ZhouChristiaan LeeuwenburghDejana BraithwaiteDongyu ZhangMDPI AGarticlesarcopeniasarcopenic obesityinflammationepidemiologyNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3957, p 3957 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sarcopenia sarcopenic obesity inflammation epidemiology Nutrition. Foods and food supply TX341-641
spellingShingle	sarcopenia sarcopenic obesity inflammation epidemiology Nutrition. Foods and food supply TX341-641 Shama D. Karanth Caretia Washington Ting-Yuan D. Cheng Daohong Zhou Christiaan Leeuwenburgh Dejana Braithwaite Dongyu Zhang Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999–2006
description	Loss of muscle mass and waning in muscle strength are common in older adults, and inflammation may play a key role in pathogenesis. This study aimed to examine associations of C-reactive protein (CRP) and systemic immune-inflammation index (SII) with sarcopenia and sarcopenic obesity in older adults with chronic comorbidities. Cross-sectional data from the National Health and Nutrition Examination Survey (1999–2006) were obtained for participants aged ≥60 years. Sarcopenia was defined by a lean mass and body height (males < 7.26 kg/m<sup>2</sup>, females < 5.45 kg/m<sup>2</sup>). Sarcopenic obesity was defined by the concurrent presence of sarcopenia and obesity (defined by relative fat mass). Logistic regression was used to assess the associations of CRP and SII with sarcopenia and sarcopenic obesity. The dose–response relationship was examined via restricted cubic splines. Of the participants (<i>n</i> = 2483), 23.1% (<i>n</i> = 574) and 7.7% (<i>n</i> = 190) had sarcopenia and sarcopenic obesity, respectively. The multivariable logistic regression models suggested a positive association of SII with sarcopenia and sarcopenic obesity, but a positive statistically significant association was not consistently observed for CRP. Dose–response curves suggested similar association patterns for these biomarkers. In clinical practice, measures to prevent sarcopenia and sarcopenic obesity are needed for older vulnerable people with high systemic inflammation.
format	article
author	Shama D. Karanth Caretia Washington Ting-Yuan D. Cheng Daohong Zhou Christiaan Leeuwenburgh Dejana Braithwaite Dongyu Zhang
author_facet	Shama D. Karanth Caretia Washington Ting-Yuan D. Cheng Daohong Zhou Christiaan Leeuwenburgh Dejana Braithwaite Dongyu Zhang
author_sort	Shama D. Karanth
title	Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999–2006
title_short	Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999–2006
title_full	Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999–2006
title_fullStr	Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999–2006
title_full_unstemmed	Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999–2006
title_sort	inflammation in relation to sarcopenia and sarcopenic obesity among older adults living with chronic comorbidities: results from the national health and nutrition examination survey 1999–2006
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6d2ce6ecf543453e9776c034634ebc91
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Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999–2006

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