The origin of glucocorticoid hormone oscillations.

Oscillating levels of adrenal glucocorticoid hormones are essential for optimal gene expression, and for maintaining physiological and behavioural responsiveness to stress. The biological basis for these oscillations is not known, but a neuronal "pulse generator" within the hypothalamus ha...

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Auteurs principaux:	Jamie J Walker, Francesca Spiga, Eleanor Waite, Zidong Zhao, Yvonne Kershaw, John R Terry, Stafford L Lightman
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2012
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/6d2f0e85b7f14d2988f07e402366fefa
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spelling	oai:doaj.org-article:6d2f0e85b7f14d2988f07e402366fefa2021-11-18T05:36:37ZThe origin of glucocorticoid hormone oscillations.1544-91731545-788510.1371/journal.pbio.1001341https://doaj.org/article/6d2f0e85b7f14d2988f07e402366fefa2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22679394/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Oscillating levels of adrenal glucocorticoid hormones are essential for optimal gene expression, and for maintaining physiological and behavioural responsiveness to stress. The biological basis for these oscillations is not known, but a neuronal "pulse generator" within the hypothalamus has remained a popular hypothesis. We demonstrate that pulsatile hypothalamic activity is not required for generating ultradian glucocorticoid oscillations. We show that a constant level of corticotrophin-releasing hormone (CRH) can activate a dynamic pituitary-adrenal peripheral network to produce ultradian adrenocorticotrophic hormone and glucocorticoid oscillations with a physiological frequency. This oscillatory response to CRH is dose dependent and becomes disrupted for higher levels of CRH. These data suggest that glucocorticoid oscillations result from a sub-hypothalamic pituitary-adrenal system, which functions as a deterministic peripheral hormone oscillator with a characteristic ultradian frequency. This constitutes a novel mechanism by which the level, rather than the pattern, of CRH determines the dynamics of glucocorticoid hormone secretion.Jamie J WalkerFrancesca SpigaEleanor WaiteZidong ZhaoYvonne KershawJohn R TerryStafford L LightmanPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 10, Iss 6, p e1001341 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jamie J Walker Francesca Spiga Eleanor Waite Zidong Zhao Yvonne Kershaw John R Terry Stafford L Lightman The origin of glucocorticoid hormone oscillations.
description	Oscillating levels of adrenal glucocorticoid hormones are essential for optimal gene expression, and for maintaining physiological and behavioural responsiveness to stress. The biological basis for these oscillations is not known, but a neuronal "pulse generator" within the hypothalamus has remained a popular hypothesis. We demonstrate that pulsatile hypothalamic activity is not required for generating ultradian glucocorticoid oscillations. We show that a constant level of corticotrophin-releasing hormone (CRH) can activate a dynamic pituitary-adrenal peripheral network to produce ultradian adrenocorticotrophic hormone and glucocorticoid oscillations with a physiological frequency. This oscillatory response to CRH is dose dependent and becomes disrupted for higher levels of CRH. These data suggest that glucocorticoid oscillations result from a sub-hypothalamic pituitary-adrenal system, which functions as a deterministic peripheral hormone oscillator with a characteristic ultradian frequency. This constitutes a novel mechanism by which the level, rather than the pattern, of CRH determines the dynamics of glucocorticoid hormone secretion.
format	article
author	Jamie J Walker Francesca Spiga Eleanor Waite Zidong Zhao Yvonne Kershaw John R Terry Stafford L Lightman
author_facet	Jamie J Walker Francesca Spiga Eleanor Waite Zidong Zhao Yvonne Kershaw John R Terry Stafford L Lightman
author_sort	Jamie J Walker
title	The origin of glucocorticoid hormone oscillations.
title_short	The origin of glucocorticoid hormone oscillations.
title_full	The origin of glucocorticoid hormone oscillations.
title_fullStr	The origin of glucocorticoid hormone oscillations.
title_full_unstemmed	The origin of glucocorticoid hormone oscillations.
title_sort	origin of glucocorticoid hormone oscillations.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6d2f0e85b7f14d2988f07e402366fefa
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The origin of glucocorticoid hormone oscillations.

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