Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste
1,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped. Here, the authors report a modular organocatalytic Mannich/Wittig/cycloisomerization sequence to access chiral 1,2-dihydropyridin...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/6d370ec84c8a4ecea03e8d81ab8c388e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | 1,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped. Here, the authors report a modular organocatalytic Mannich/Wittig/cycloisomerization sequence to access chiral 1,2-dihydropyridines from N-Boc aldimines, aldehydes and phosphoranes, using a chiral amine catalyst. |
|---|