Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste

1,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped. Here, the authors report a modular organocatalytic Mannich/Wittig/cycloisomerization sequence to access chiral 1,2-dihydropyridin...

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Autores principales:	Bo-Shuai Mu, Xiao-Yuan Cui, Xing-Ping Zeng, Jin-Sheng Yu, Jian Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d370ec84c8a4ecea03e8d81ab8c388e
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spelling	oai:doaj.org-article:6d370ec84c8a4ecea03e8d81ab8c388e2021-12-02T14:26:56ZModular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste10.1038/s41467-021-22374-y2041-1723https://doaj.org/article/6d370ec84c8a4ecea03e8d81ab8c388e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22374-yhttps://doaj.org/toc/2041-17231,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped. Here, the authors report a modular organocatalytic Mannich/Wittig/cycloisomerization sequence to access chiral 1,2-dihydropyridines from N-Boc aldimines, aldehydes and phosphoranes, using a chiral amine catalyst.Bo-Shuai MuXiao-Yuan CuiXing-Ping ZengJin-Sheng YuJian ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo-Shuai Mu Xiao-Yuan Cui Xing-Ping Zeng Jin-Sheng Yu Jian Zhou Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste
description	1,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped. Here, the authors report a modular organocatalytic Mannich/Wittig/cycloisomerization sequence to access chiral 1,2-dihydropyridines from N-Boc aldimines, aldehydes and phosphoranes, using a chiral amine catalyst.
format	article
author	Bo-Shuai Mu Xiao-Yuan Cui Xing-Ping Zeng Jin-Sheng Yu Jian Zhou
author_facet	Bo-Shuai Mu Xiao-Yuan Cui Xing-Ping Zeng Jin-Sheng Yu Jian Zhou
author_sort	Bo-Shuai Mu
title	Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste
title_short	Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste
title_full	Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste
title_fullStr	Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste
title_full_unstemmed	Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste
title_sort	modular synthesis of chiral 1,2-dihydropyridines via mannich/wittig/cycloisomerization sequence that internally reuses waste
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6d370ec84c8a4ecea03e8d81ab8c388e
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Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste

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