Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate

The acetyltransferase Tip60 mediates signaling pathways by acetylating non-histone proteins. Here the authors show that fatty acids induce Tip60–dependent acetylation of phosphatidic acid phosphatase lipin1 which, then, translocates to the ER and generates diacylglycerols for triglyceride synthesis....

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Autores principales:	Terytty Yang Li, Lintao Song, Yu Sun, Jingyi Li, Cong Yi, Sin Man Lam, Dijin Xu, Linkang Zhou, Xiaotong Li, Ying Yang, Chen-Song Zhang, Changchuan Xie, Xi Huang, Guanghou Shui, Shu-Yong Lin, Karen Reue, Sheng-Cai Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d3a8b03800847849d6650fc252e7166
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:6d3a8b03800847849d6650fc252e71662021-12-02T16:56:41ZTip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate10.1038/s41467-018-04363-w2041-1723https://doaj.org/article/6d3a8b03800847849d6650fc252e71662018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04363-whttps://doaj.org/toc/2041-1723The acetyltransferase Tip60 mediates signaling pathways by acetylating non-histone proteins. Here the authors show that fatty acids induce Tip60–dependent acetylation of phosphatidic acid phosphatase lipin1 which, then, translocates to the ER and generates diacylglycerols for triglyceride synthesis.Terytty Yang LiLintao SongYu SunJingyi LiCong YiSin Man LamDijin XuLinkang ZhouXiaotong LiYing YangChen-Song ZhangChangchuan XieXi HuangGuanghou ShuiShu-Yong LinKaren ReueSheng-Cai LinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Terytty Yang Li Lintao Song Yu Sun Jingyi Li Cong Yi Sin Man Lam Dijin Xu Linkang Zhou Xiaotong Li Ying Yang Chen-Song Zhang Changchuan Xie Xi Huang Guanghou Shui Shu-Yong Lin Karen Reue Sheng-Cai Lin Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate
description	The acetyltransferase Tip60 mediates signaling pathways by acetylating non-histone proteins. Here the authors show that fatty acids induce Tip60–dependent acetylation of phosphatidic acid phosphatase lipin1 which, then, translocates to the ER and generates diacylglycerols for triglyceride synthesis.
format	article
author	Terytty Yang Li Lintao Song Yu Sun Jingyi Li Cong Yi Sin Man Lam Dijin Xu Linkang Zhou Xiaotong Li Ying Yang Chen-Song Zhang Changchuan Xie Xi Huang Guanghou Shui Shu-Yong Lin Karen Reue Sheng-Cai Lin
author_facet	Terytty Yang Li Lintao Song Yu Sun Jingyi Li Cong Yi Sin Man Lam Dijin Xu Linkang Zhou Xiaotong Li Ying Yang Chen-Song Zhang Changchuan Xie Xi Huang Guanghou Shui Shu-Yong Lin Karen Reue Sheng-Cai Lin
author_sort	Terytty Yang Li
title	Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate
title_short	Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate
title_full	Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate
title_fullStr	Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate
title_full_unstemmed	Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate
title_sort	tip60-mediated lipin 1 acetylation and er translocation determine triacylglycerol synthesis rate
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6d3a8b03800847849d6650fc252e7166
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Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate

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