Wwp2 maintains cartilage homeostasis through regulation of Adamts5

Wwp2 maintains cartilage homeostasis through regulation of Adamts5

Wwp2 is an HECT-type E3 ubiquitin ligase abundantly expressed in articular cartilage. Here, the authors show that in mice, loss of Wwp2 leads to upregulated Runx2-Adamts5 signaling in articular cartilage and development of osteoarthritis, and that disease severity is reduced by injection of Wwp2 mRN...

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Autores principales: Sho Mokuda, Ryo Nakamichi, Tokio Matsuzaki, Yoshiaki Ito, Tempei Sato, Kohei Miyata, Masafumi Inui, Merissa Olmer, Eiji Sugiyama, Martin Lotz, Hiroshi Asahara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/6d3f9987d5c04d849d14252ac998b87e
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spelling oai:doaj.org-article:6d3f9987d5c04d849d14252ac998b87e2021-12-02T16:58:25ZWwp2 maintains cartilage homeostasis through regulation of Adamts510.1038/s41467-019-10177-12041-1723https://doaj.org/article/6d3f9987d5c04d849d14252ac998b87e2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10177-1https://doaj.org/toc/2041-1723Wwp2 is an HECT-type E3 ubiquitin ligase abundantly expressed in articular cartilage. Here, the authors show that in mice, loss of Wwp2 leads to upregulated Runx2-Adamts5 signaling in articular cartilage and development of osteoarthritis, and that disease severity is reduced by injection of Wwp2 mRNASho MokudaRyo NakamichiTokio MatsuzakiYoshiaki ItoTempei SatoKohei MiyataMasafumi InuiMerissa OlmerEiji SugiyamaMartin LotzHiroshi AsaharaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sho Mokuda
Ryo Nakamichi
Tokio Matsuzaki
Yoshiaki Ito
Tempei Sato
Kohei Miyata
Masafumi Inui
Merissa Olmer
Eiji Sugiyama
Martin Lotz
Hiroshi Asahara
Wwp2 maintains cartilage homeostasis through regulation of Adamts5
description Wwp2 is an HECT-type E3 ubiquitin ligase abundantly expressed in articular cartilage. Here, the authors show that in mice, loss of Wwp2 leads to upregulated Runx2-Adamts5 signaling in articular cartilage and development of osteoarthritis, and that disease severity is reduced by injection of Wwp2 mRNA
format article
author Sho Mokuda
Ryo Nakamichi
Tokio Matsuzaki
Yoshiaki Ito
Tempei Sato
Kohei Miyata
Masafumi Inui
Merissa Olmer
Eiji Sugiyama
Martin Lotz
Hiroshi Asahara
author_facet Sho Mokuda
Ryo Nakamichi
Tokio Matsuzaki
Yoshiaki Ito
Tempei Sato
Kohei Miyata
Masafumi Inui
Merissa Olmer
Eiji Sugiyama
Martin Lotz
Hiroshi Asahara
author_sort Sho Mokuda
title Wwp2 maintains cartilage homeostasis through regulation of Adamts5
title_short Wwp2 maintains cartilage homeostasis through regulation of Adamts5
title_full Wwp2 maintains cartilage homeostasis through regulation of Adamts5
title_fullStr Wwp2 maintains cartilage homeostasis through regulation of Adamts5
title_full_unstemmed Wwp2 maintains cartilage homeostasis through regulation of Adamts5
title_sort wwp2 maintains cartilage homeostasis through regulation of adamts5
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/6d3f9987d5c04d849d14252ac998b87e
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