Photoredox-catalyzed branch-selective pyridylation of alkenes for the expedient synthesis of Triprolidine

Alkenylpyridines are versatile building blocks for the synthesis of drugs and other complex molecular structures. Here, the authors show a branch-selective pyridylation of alkenes via sulfinate-assisted photoredox catalysis and showcase its utility in an expedient synthesis of Triprolidine.

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Detalles Bibliográficos
Autores principales: Shengqing Zhu, Jian Qin, Fang Wang, Huan Li, Lingling Chu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/6d40b876cb7e4c64b129ff5e1e8b18a8
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Sumario:Alkenylpyridines are versatile building blocks for the synthesis of drugs and other complex molecular structures. Here, the authors show a branch-selective pyridylation of alkenes via sulfinate-assisted photoredox catalysis and showcase its utility in an expedient synthesis of Triprolidine.