Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth

BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress. Here the authors show that USP21 regulates the ability of tumor cells to repair damaged DNA by regulating BRCA2 stability.

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Autores principales:	Jinping Liu, Alex Kruswick, Hien Dang, Andy D. Tran, So Mee Kwon, Xin Wei Wang, Philipp Oberdoerffer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d416f5188234f9fa281c79b9c130b8a
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spelling	oai:doaj.org-article:6d416f5188234f9fa281c79b9c130b8a2021-12-02T14:16:55ZUbiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth10.1038/s41467-017-00206-22041-1723https://doaj.org/article/6d416f5188234f9fa281c79b9c130b8a2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00206-2https://doaj.org/toc/2041-1723BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress. Here the authors show that USP21 regulates the ability of tumor cells to repair damaged DNA by regulating BRCA2 stability.Jinping LiuAlex KruswickHien DangAndy D. TranSo Mee KwonXin Wei WangPhilipp OberdoerfferNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinping Liu Alex Kruswick Hien Dang Andy D. Tran So Mee Kwon Xin Wei Wang Philipp Oberdoerffer Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
description	BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress. Here the authors show that USP21 regulates the ability of tumor cells to repair damaged DNA by regulating BRCA2 stability.
format	article
author	Jinping Liu Alex Kruswick Hien Dang Andy D. Tran So Mee Kwon Xin Wei Wang Philipp Oberdoerffer
author_facet	Jinping Liu Alex Kruswick Hien Dang Andy D. Tran So Mee Kwon Xin Wei Wang Philipp Oberdoerffer
author_sort	Jinping Liu
title	Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
title_short	Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
title_full	Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
title_fullStr	Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
title_full_unstemmed	Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
title_sort	ubiquitin-specific protease 21 stabilizes brca2 to control dna repair and tumor growth
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6d416f5188234f9fa281c79b9c130b8a
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Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth

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