The management of hemophilia in elderly patients

Massimo Franchini1, Annarita Tagliaferri2, Pier Mannuccio Mannucci31Transfusion and Hemophilia Center, City Hospital of Verona, Italy; 2Regional Reference Center for Inherited Bleeding Disorders, University Hospital of Parma, Italy; 3Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Departm...

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Autores principales:	Massimo Franchini, Annarita Tagliaferri, Pier Mannuccio Mannucci
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/6d44f70829914356a5b0898051994c57
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spelling	oai:doaj.org-article:6d44f70829914356a5b0898051994c572021-12-02T03:37:57ZThe management of hemophilia in elderly patients1178-1998https://doaj.org/article/6d44f70829914356a5b0898051994c572007-10-01T00:00:00Zhttps://www.dovepress.com/the-management-of-hemophilia-in-elderly-patients-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Massimo Franchini1, Annarita Tagliaferri2, Pier Mannuccio Mannucci31Transfusion and Hemophilia Center, City Hospital of Verona, Italy; 2Regional Reference Center for Inherited Bleeding Disorders, University Hospital of Parma, Italy; 3Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Department of Medicine and Medical Specialties, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, University of Milan, ItalyAbstract: After the increasing rate of deaths observed during the 1980s due to human immunodeficiency virus (HIV) infection, the health-related quality of life and life expectancy of persons with hemophilia have improved, mainly due to the progresses of replacement therapy and antiviral drugs and to the improvement of the global comprehensive care provided by specialized centers. As a consequence, an increasing number of hemophiliacs have reached an older age and nowadays physicians in hemophilia centers find that they must handle age-related clinical problems never previously observed in this population. The management of elderly persons with congenital hemophilia is discussed in the first part of this review. The second part describes the general aspects of acquired hemophilia due to anti-factor VIII autoantibodies, focusing on the clinical management of elderly patients, one of the groups most frequently affected by this acquired bleeding disorder.Keywords: hemophilia, factor VIII, elderly, aging, inhibitors, bleedingMassimo FranchiniAnnarita TagliaferriPier Mannuccio MannucciDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 361-368 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Massimo Franchini Annarita Tagliaferri Pier Mannuccio Mannucci The management of hemophilia in elderly patients
description	Massimo Franchini1, Annarita Tagliaferri2, Pier Mannuccio Mannucci31Transfusion and Hemophilia Center, City Hospital of Verona, Italy; 2Regional Reference Center for Inherited Bleeding Disorders, University Hospital of Parma, Italy; 3Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Department of Medicine and Medical Specialties, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, University of Milan, ItalyAbstract: After the increasing rate of deaths observed during the 1980s due to human immunodeficiency virus (HIV) infection, the health-related quality of life and life expectancy of persons with hemophilia have improved, mainly due to the progresses of replacement therapy and antiviral drugs and to the improvement of the global comprehensive care provided by specialized centers. As a consequence, an increasing number of hemophiliacs have reached an older age and nowadays physicians in hemophilia centers find that they must handle age-related clinical problems never previously observed in this population. The management of elderly persons with congenital hemophilia is discussed in the first part of this review. The second part describes the general aspects of acquired hemophilia due to anti-factor VIII autoantibodies, focusing on the clinical management of elderly patients, one of the groups most frequently affected by this acquired bleeding disorder.Keywords: hemophilia, factor VIII, elderly, aging, inhibitors, bleeding
format	article
author	Massimo Franchini Annarita Tagliaferri Pier Mannuccio Mannucci
author_facet	Massimo Franchini Annarita Tagliaferri Pier Mannuccio Mannucci
author_sort	Massimo Franchini
title	The management of hemophilia in elderly patients
title_short	The management of hemophilia in elderly patients
title_full	The management of hemophilia in elderly patients
title_fullStr	The management of hemophilia in elderly patients
title_full_unstemmed	The management of hemophilia in elderly patients
title_sort	management of hemophilia in elderly patients
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/6d44f70829914356a5b0898051994c57
work_keys_str_mv	AT massimofranchini themanagementofhemophiliainelderlypatients AT annaritatagliaferri themanagementofhemophiliainelderlypatients AT piermannucciomannucci themanagementofhemophiliainelderlypatients AT massimofranchini managementofhemophiliainelderlypatients AT annaritatagliaferri managementofhemophiliainelderlypatients AT piermannucciomannucci managementofhemophiliainelderlypatients
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The management of hemophilia in elderly patients

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