Estrogen receptor status in relation to risk of contralateral breast cancer-a population-based cohort study.

<h4>Background</h4>It is unclear whether estrogen receptor (ER)-status of first primary breast cancer is associated with risk of metachronous (non-simultaneous) contralateral breast cancer (CBC), and to what extent endocrine therapy affects this association.<h4>Methods</h4>We...

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Autores principales:	Maria E C Sandberg, Per Hall, Mikael Hartman, Anna L V Johansson, Sandra Eloranta, Alexander Ploner, Kamila Czene
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d4d51021e6c40a9a16deba2ab70cfd1
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spelling	oai:doaj.org-article:6d4d51021e6c40a9a16deba2ab70cfd12021-11-18T08:12:55ZEstrogen receptor status in relation to risk of contralateral breast cancer-a population-based cohort study.1932-620310.1371/journal.pone.0046535https://doaj.org/article/6d4d51021e6c40a9a16deba2ab70cfd12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23056335/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>It is unclear whether estrogen receptor (ER)-status of first primary breast cancer is associated with risk of metachronous (non-simultaneous) contralateral breast cancer (CBC), and to what extent endocrine therapy affects this association.<h4>Methods</h4>We studied the effect of ER-status of the first cancer on the risk of CBC overall, and for different ER-subtypes of CBC, using a large, population-based cohort. The cohort consisted of all women diagnosed with breast cancer in the Stockholm region 1976-2005; 25715 patients, of whom 940 suffered CBC. The relative risk was analyzed mainly using standardized incidence ratios (SIR).<h4>Results</h4>Women with breast cancer had a doubled risk of CBC compared to the risk of breast cancer in the general female population (SIR: 2.22 [2.08-2.36]), for women with a previous ER-positive cancer: SIR=2.30 (95% CI:2.11-2.50) and for women with a previous ER-negative cancer: SIR=2.17 (95% CI:1.82-2.55). The relative risk of ER-positive and ER-negative CBC was very similar for women with ER-positive first cancer (SIR=2.02 [95%CI: 1.80-2.27] and SIR=1.89 [95%CI: 1.46-2.41] respectively) while for patients with ER-negative first cancer the relative risk was significantly different (SIR=1.27 [95% CI:0.94-1.68] for ER-positive CBC and SIR=4.96 [95%CI:3.67-6.56] for ER-negative CBC). Patients with ER-positive first cancer who received hormone therapy still had a significantly higher risk of CBC than the risk of breast cancer for the general female population (SIR=1.74 [95% CI:1.47-2.03]).<h4>Conclusion</h4>The risk of CBC for a breast cancer patient is increased to about two-fold, compared to the risk of breast cancer in the general female population. This excess risk decreases, but does not disappear, with adjuvant endocrine therapy. Patients with ER-positive first cancers have an increased risk for CBC of both ER subtypes, while patients with ER-negative first cancer have a specifically increased risk of ER-negative CBC.Maria E C SandbergPer HallMikael HartmanAnna L V JohanssonSandra ElorantaAlexander PlonerKamila CzenePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e46535 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria E C Sandberg Per Hall Mikael Hartman Anna L V Johansson Sandra Eloranta Alexander Ploner Kamila Czene Estrogen receptor status in relation to risk of contralateral breast cancer-a population-based cohort study.
description	<h4>Background</h4>It is unclear whether estrogen receptor (ER)-status of first primary breast cancer is associated with risk of metachronous (non-simultaneous) contralateral breast cancer (CBC), and to what extent endocrine therapy affects this association.<h4>Methods</h4>We studied the effect of ER-status of the first cancer on the risk of CBC overall, and for different ER-subtypes of CBC, using a large, population-based cohort. The cohort consisted of all women diagnosed with breast cancer in the Stockholm region 1976-2005; 25715 patients, of whom 940 suffered CBC. The relative risk was analyzed mainly using standardized incidence ratios (SIR).<h4>Results</h4>Women with breast cancer had a doubled risk of CBC compared to the risk of breast cancer in the general female population (SIR: 2.22 [2.08-2.36]), for women with a previous ER-positive cancer: SIR=2.30 (95% CI:2.11-2.50) and for women with a previous ER-negative cancer: SIR=2.17 (95% CI:1.82-2.55). The relative risk of ER-positive and ER-negative CBC was very similar for women with ER-positive first cancer (SIR=2.02 [95%CI: 1.80-2.27] and SIR=1.89 [95%CI: 1.46-2.41] respectively) while for patients with ER-negative first cancer the relative risk was significantly different (SIR=1.27 [95% CI:0.94-1.68] for ER-positive CBC and SIR=4.96 [95%CI:3.67-6.56] for ER-negative CBC). Patients with ER-positive first cancer who received hormone therapy still had a significantly higher risk of CBC than the risk of breast cancer for the general female population (SIR=1.74 [95% CI:1.47-2.03]).<h4>Conclusion</h4>The risk of CBC for a breast cancer patient is increased to about two-fold, compared to the risk of breast cancer in the general female population. This excess risk decreases, but does not disappear, with adjuvant endocrine therapy. Patients with ER-positive first cancers have an increased risk for CBC of both ER subtypes, while patients with ER-negative first cancer have a specifically increased risk of ER-negative CBC.
format	article
author	Maria E C Sandberg Per Hall Mikael Hartman Anna L V Johansson Sandra Eloranta Alexander Ploner Kamila Czene
author_facet	Maria E C Sandberg Per Hall Mikael Hartman Anna L V Johansson Sandra Eloranta Alexander Ploner Kamila Czene
author_sort	Maria E C Sandberg
title	Estrogen receptor status in relation to risk of contralateral breast cancer-a population-based cohort study.
title_short	Estrogen receptor status in relation to risk of contralateral breast cancer-a population-based cohort study.
title_full	Estrogen receptor status in relation to risk of contralateral breast cancer-a population-based cohort study.
title_fullStr	Estrogen receptor status in relation to risk of contralateral breast cancer-a population-based cohort study.
title_full_unstemmed	Estrogen receptor status in relation to risk of contralateral breast cancer-a population-based cohort study.
title_sort	estrogen receptor status in relation to risk of contralateral breast cancer-a population-based cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6d4d51021e6c40a9a16deba2ab70cfd1
work_keys_str_mv	AT mariaecsandberg estrogenreceptorstatusinrelationtoriskofcontralateralbreastcancerapopulationbasedcohortstudy AT perhall estrogenreceptorstatusinrelationtoriskofcontralateralbreastcancerapopulationbasedcohortstudy AT mikaelhartman estrogenreceptorstatusinrelationtoriskofcontralateralbreastcancerapopulationbasedcohortstudy AT annalvjohansson estrogenreceptorstatusinrelationtoriskofcontralateralbreastcancerapopulationbasedcohortstudy AT sandraeloranta estrogenreceptorstatusinrelationtoriskofcontralateralbreastcancerapopulationbasedcohortstudy AT alexanderploner estrogenreceptorstatusinrelationtoriskofcontralateralbreastcancerapopulationbasedcohortstudy AT kamilaczene estrogenreceptorstatusinrelationtoriskofcontralateralbreastcancerapopulationbasedcohortstudy
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Estrogen receptor status in relation to risk of contralateral breast cancer-a population-based cohort study.

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