The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis

Increased soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) levels have been reported in patients with sepsis. We tested the hypotheses that serum sTREM-1 levels increase in the early phase of sepsis and decrease after sepsis under appropriate treatment and that sTREM-1 levels can p...

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Autores principales:	Chia-Te Kung, Chih-Min Su, Sheng-Yuan Hsiao, Fu-Cheng Chen, Yun-Ru Lai, Chih-Cheng Huang, Cheng-Hsien Lu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hospital mortality sTREM-1 sepsis outcome Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6d4f7d7e1b9b4629ba439d5656c790ca
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spelling	oai:doaj.org-article:6d4f7d7e1b9b4629ba439d5656c790ca2021-11-25T17:20:26ZThe Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis10.3390/diagnostics111119792075-4418https://doaj.org/article/6d4f7d7e1b9b4629ba439d5656c790ca2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1979https://doaj.org/toc/2075-4418Increased soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) levels have been reported in patients with sepsis. We tested the hypotheses that serum sTREM-1 levels increase in the early phase of sepsis and decrease after sepsis under appropriate treatment and that sTREM-1 levels can predict therapeutic outcomes. One hundred and fifty-five patients prospectively underwent blood samples including biochemical data, sTREM-1, and biomarkers on endothelial dysfunction as well as clinical severity index examinations. Blood samples from Days 1, 4, and 7 after admission were checked. For comparison, 50 healthy subjects were selected as healthy control. Those patients who had sepsis had significantly higher sTREM-1 levels than those of healthy control. sTREM-1 levels positively correlated with biomarkers for endothelial dysfunction (ICAM-1, VCAM-1, and E-selectin) and lactate level as well as clinical severity index (maximum 24 h APACHE score and Sequential Organ Failure Assessment (SOFA) score) upon admission. sTREM-1 concentrations were significantly higher from Day 1 to Day 7 in the non-survivors than in the survivors. A stepwise logistic regression analysis showed only sTREM-1 level and maximum 24 h SOFA score upon admission were significantly associated with fatality. Area under the receiver operating characteristic curve analysis for the diagnostic accuracy of sTREM-1 in sepsis-related fatality gave a value of 0.726, with a cutoff value of 384.6 pg/mL (sensitivity = 80.8% and specificity = 61.5%). sTREM-1 level may be valuable in auxiliary diagnosis, and it can serve as a useful biomarker as a screening service and follow-up therapeutic outcomes in sepsis.Chia-Te KungChih-Min SuSheng-Yuan HsiaoFu-Cheng ChenYun-Ru LaiChih-Cheng HuangCheng-Hsien LuMDPI AGarticlehospital mortalitysTREM-1sepsisoutcomeMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1979, p 1979 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hospital mortality sTREM-1 sepsis outcome Medicine (General) R5-920
spellingShingle	hospital mortality sTREM-1 sepsis outcome Medicine (General) R5-920 Chia-Te Kung Chih-Min Su Sheng-Yuan Hsiao Fu-Cheng Chen Yun-Ru Lai Chih-Cheng Huang Cheng-Hsien Lu The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
description	Increased soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) levels have been reported in patients with sepsis. We tested the hypotheses that serum sTREM-1 levels increase in the early phase of sepsis and decrease after sepsis under appropriate treatment and that sTREM-1 levels can predict therapeutic outcomes. One hundred and fifty-five patients prospectively underwent blood samples including biochemical data, sTREM-1, and biomarkers on endothelial dysfunction as well as clinical severity index examinations. Blood samples from Days 1, 4, and 7 after admission were checked. For comparison, 50 healthy subjects were selected as healthy control. Those patients who had sepsis had significantly higher sTREM-1 levels than those of healthy control. sTREM-1 levels positively correlated with biomarkers for endothelial dysfunction (ICAM-1, VCAM-1, and E-selectin) and lactate level as well as clinical severity index (maximum 24 h APACHE score and Sequential Organ Failure Assessment (SOFA) score) upon admission. sTREM-1 concentrations were significantly higher from Day 1 to Day 7 in the non-survivors than in the survivors. A stepwise logistic regression analysis showed only sTREM-1 level and maximum 24 h SOFA score upon admission were significantly associated with fatality. Area under the receiver operating characteristic curve analysis for the diagnostic accuracy of sTREM-1 in sepsis-related fatality gave a value of 0.726, with a cutoff value of 384.6 pg/mL (sensitivity = 80.8% and specificity = 61.5%). sTREM-1 level may be valuable in auxiliary diagnosis, and it can serve as a useful biomarker as a screening service and follow-up therapeutic outcomes in sepsis.
format	article
author	Chia-Te Kung Chih-Min Su Sheng-Yuan Hsiao Fu-Cheng Chen Yun-Ru Lai Chih-Cheng Huang Cheng-Hsien Lu
author_facet	Chia-Te Kung Chih-Min Su Sheng-Yuan Hsiao Fu-Cheng Chen Yun-Ru Lai Chih-Cheng Huang Cheng-Hsien Lu
author_sort	Chia-Te Kung
title	The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
title_short	The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
title_full	The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
title_fullStr	The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
title_full_unstemmed	The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
title_sort	prognostic value of serum soluble trem-1 on outcome in adult patients with sepsis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6d4f7d7e1b9b4629ba439d5656c790ca
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The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis

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