Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study

Cuili Kuang, Yunfei ZhaRadiological Department, Renmin Hospital of Wuhan University, Hubei, People’s Republic of ChinaCorrespondence: Yunfei ZhaRadiological Department, Renmin Hospital of Wuhan University, No.99 ZhangZhiDong Road, Wuchang District, Wuhan, Hubei 430060, People’s R...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kuang C, Zha Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	ALFF ReHo Seed-based functional connectivity Cervical spondylotic myelopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6d53161eccf44dac97f7a3eb25204cc0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6d53161eccf44dac97f7a3eb25204cc0
record_format	dspace
spelling	oai:doaj.org-article:6d53161eccf44dac97f7a3eb25204cc02021-12-02T10:55:22ZAbnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study1178-2021https://doaj.org/article/6d53161eccf44dac97f7a3eb25204cc02019-08-01T00:00:00Zhttps://www.dovepress.com/abnormal-intrinsic-functional-activity-in-patients-with-cervical-spond-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Cuili Kuang, Yunfei ZhaRadiological Department, Renmin Hospital of Wuhan University, Hubei, People’s Republic of ChinaCorrespondence: Yunfei ZhaRadiological Department, Renmin Hospital of Wuhan University, No.99 ZhangZhiDong Road, Wuchang District, Wuhan, Hubei 430060, People’s Republic of ChinaTel +86 135 5406 1833Email fskyanteam@126.comPurpose: We employed resting-state fMRI analyses to reveal central functional reorganization in the brains of patients with cervical spondylotic myelopathy (CSM) and to provide complementary evidence of cortex reorganization in these patients.Patients and methods: We obtained Fisher’s z transformation amplitude of low-frequency fluctuations (zALFF) and Fisher’s z transformation regional homogeneity (zReHo) measurements from 33 patients with CSM and 33 healthy controls (HC) and used the brain regions with significant alterations in the zALFF or zReHo values as seed regions. Then, we calculated Pearson’s correlation coefficients between the resting-state time courses of each seed and the time series of the rest of the brain. Lastly, we computed correlations between the altered zALFF, zReHo, and functional connectivity with Japanese Orthopaedic Association scores, Neck Disability Index score, and the duration of symptoms in patients with CSM.Results: zALFF and zReHo values were increased in the left medial superior frontal gyrus (lSFGmed) and left supramarginal gyrus (lSMG) in patients with CSM compared with those in the HC group. Selecting lSFGmed as the seed, we observed increased functional connectivity between it and the left postcentral gyrus (lPoCG) and left rolandic operculum and decreased functional connectivity with the right medial superior frontal gyrus in patients with CSM. In addition, there was a significant increase in the functional connectivity between the lSMG (seed) and the left calcarine and lPoCG in patients with CSM. However, we did not find any significant correlation between the resting-state findings and the clinical performance of patients with CSM.Conclusion: These observed intrinsic functional changes in the patients with CSM may be related to functional reorganization and reflect the innate cortical plasticity in patients with CSM. Notably, the increased connectivity between the lPoCG and the two seed ROIs indicates the adaptive changes in patients with CSM. These findings provide complementary evidence of cortex reorganization in CSM.Keywords: ALFF, ReHo, seed-based functional connectivity, cervical spondylotic myelopathyKuang CZha YDove Medical PressarticleALFFReHoSeed-based functional connectivityCervical spondylotic myelopathyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2371-2383 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ALFF ReHo Seed-based functional connectivity Cervical spondylotic myelopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	ALFF ReHo Seed-based functional connectivity Cervical spondylotic myelopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kuang C Zha Y Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study
description	Cuili Kuang, Yunfei ZhaRadiological Department, Renmin Hospital of Wuhan University, Hubei, People’s Republic of ChinaCorrespondence: Yunfei ZhaRadiological Department, Renmin Hospital of Wuhan University, No.99 ZhangZhiDong Road, Wuchang District, Wuhan, Hubei 430060, People’s Republic of ChinaTel +86 135 5406 1833Email fskyanteam@126.comPurpose: We employed resting-state fMRI analyses to reveal central functional reorganization in the brains of patients with cervical spondylotic myelopathy (CSM) and to provide complementary evidence of cortex reorganization in these patients.Patients and methods: We obtained Fisher’s z transformation amplitude of low-frequency fluctuations (zALFF) and Fisher’s z transformation regional homogeneity (zReHo) measurements from 33 patients with CSM and 33 healthy controls (HC) and used the brain regions with significant alterations in the zALFF or zReHo values as seed regions. Then, we calculated Pearson’s correlation coefficients between the resting-state time courses of each seed and the time series of the rest of the brain. Lastly, we computed correlations between the altered zALFF, zReHo, and functional connectivity with Japanese Orthopaedic Association scores, Neck Disability Index score, and the duration of symptoms in patients with CSM.Results: zALFF and zReHo values were increased in the left medial superior frontal gyrus (lSFGmed) and left supramarginal gyrus (lSMG) in patients with CSM compared with those in the HC group. Selecting lSFGmed as the seed, we observed increased functional connectivity between it and the left postcentral gyrus (lPoCG) and left rolandic operculum and decreased functional connectivity with the right medial superior frontal gyrus in patients with CSM. In addition, there was a significant increase in the functional connectivity between the lSMG (seed) and the left calcarine and lPoCG in patients with CSM. However, we did not find any significant correlation between the resting-state findings and the clinical performance of patients with CSM.Conclusion: These observed intrinsic functional changes in the patients with CSM may be related to functional reorganization and reflect the innate cortical plasticity in patients with CSM. Notably, the increased connectivity between the lPoCG and the two seed ROIs indicates the adaptive changes in patients with CSM. These findings provide complementary evidence of cortex reorganization in CSM.Keywords: ALFF, ReHo, seed-based functional connectivity, cervical spondylotic myelopathy
format	article
author	Kuang C Zha Y
author_facet	Kuang C Zha Y
author_sort	Kuang C
title	Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study
title_short	Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study
title_full	Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study
title_fullStr	Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study
title_full_unstemmed	Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study
title_sort	abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fmri study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/6d53161eccf44dac97f7a3eb25204cc0
work_keys_str_mv	AT kuangc abnormalintrinsicfunctionalactivityinpatientswithcervicalspondyloticmyelopathyarestingstatefmristudy AT zhay abnormalintrinsicfunctionalactivityinpatientswithcervicalspondyloticmyelopathyarestingstatefmristudy
_version_	1718396474626146304

Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study

Ejemplares similares