Tau binding protein CAPON induces tau aggregation and neurodegeneration

To understand the molecular processes that link Aβ amyloidosis, tauopathy and neurodegeneration, the authors screened for tau-interacting proteins. They demonstrated that a novel tau binding protein CAPON accelerates tau pathology and neuronal cell death in an Alzheimer’s disease mouse model.

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Autores principales:	Shoko Hashimoto, Yukio Matsuba, Naoko Kamano, Naomi Mihira, Naruhiko Sahara, Jiro Takano, Shin-ichi Muramatsu, Takaomi C. Saido, Takashi Saito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d5539c0c38d49df96dcc5ad495fe5b8
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spelling	oai:doaj.org-article:6d5539c0c38d49df96dcc5ad495fe5b82021-12-02T16:57:54ZTau binding protein CAPON induces tau aggregation and neurodegeneration10.1038/s41467-019-10278-x2041-1723https://doaj.org/article/6d5539c0c38d49df96dcc5ad495fe5b82019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10278-xhttps://doaj.org/toc/2041-1723To understand the molecular processes that link Aβ amyloidosis, tauopathy and neurodegeneration, the authors screened for tau-interacting proteins. They demonstrated that a novel tau binding protein CAPON accelerates tau pathology and neuronal cell death in an Alzheimer’s disease mouse model.Shoko HashimotoYukio MatsubaNaoko KamanoNaomi MihiraNaruhiko SaharaJiro TakanoShin-ichi MuramatsuTakaomi C. SaidoTakashi SaitoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shoko Hashimoto Yukio Matsuba Naoko Kamano Naomi Mihira Naruhiko Sahara Jiro Takano Shin-ichi Muramatsu Takaomi C. Saido Takashi Saito Tau binding protein CAPON induces tau aggregation and neurodegeneration
description	To understand the molecular processes that link Aβ amyloidosis, tauopathy and neurodegeneration, the authors screened for tau-interacting proteins. They demonstrated that a novel tau binding protein CAPON accelerates tau pathology and neuronal cell death in an Alzheimer’s disease mouse model.
format	article
author	Shoko Hashimoto Yukio Matsuba Naoko Kamano Naomi Mihira Naruhiko Sahara Jiro Takano Shin-ichi Muramatsu Takaomi C. Saido Takashi Saito
author_facet	Shoko Hashimoto Yukio Matsuba Naoko Kamano Naomi Mihira Naruhiko Sahara Jiro Takano Shin-ichi Muramatsu Takaomi C. Saido Takashi Saito
author_sort	Shoko Hashimoto
title	Tau binding protein CAPON induces tau aggregation and neurodegeneration
title_short	Tau binding protein CAPON induces tau aggregation and neurodegeneration
title_full	Tau binding protein CAPON induces tau aggregation and neurodegeneration
title_fullStr	Tau binding protein CAPON induces tau aggregation and neurodegeneration
title_full_unstemmed	Tau binding protein CAPON induces tau aggregation and neurodegeneration
title_sort	tau binding protein capon induces tau aggregation and neurodegeneration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6d5539c0c38d49df96dcc5ad495fe5b8
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Tau binding protein CAPON induces tau aggregation and neurodegeneration

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