Direct quality control of glycoengineered erythropoietin variants

Several therapeutics are glycosylated proteins, yet the analysis of their specific glycosylation patterns remains challenging. Here the authors demonstrate an approach for the detailed characterization of glycosylated biopharmaceuticals applied to the determination of the glycoproteoform profile of...

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Autores principales:	Tomislav Čaval, Weihua Tian, Zhang Yang, Henrik Clausen, Albert J. R. Heck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d591091bbd4425594268aada88a4112
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spelling	oai:doaj.org-article:6d591091bbd4425594268aada88a41122021-12-02T15:33:59ZDirect quality control of glycoengineered erythropoietin variants10.1038/s41467-018-05536-32041-1723https://doaj.org/article/6d591091bbd4425594268aada88a41122018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05536-3https://doaj.org/toc/2041-1723Several therapeutics are glycosylated proteins, yet the analysis of their specific glycosylation patterns remains challenging. Here the authors demonstrate an approach for the detailed characterization of glycosylated biopharmaceuticals applied to the determination of the glycoproteoform profile of glycoengineered variants of erythropoietin.Tomislav ČavalWeihua TianZhang YangHenrik ClausenAlbert J. R. HeckNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomislav Čaval Weihua Tian Zhang Yang Henrik Clausen Albert J. R. Heck Direct quality control of glycoengineered erythropoietin variants
description	Several therapeutics are glycosylated proteins, yet the analysis of their specific glycosylation patterns remains challenging. Here the authors demonstrate an approach for the detailed characterization of glycosylated biopharmaceuticals applied to the determination of the glycoproteoform profile of glycoengineered variants of erythropoietin.
format	article
author	Tomislav Čaval Weihua Tian Zhang Yang Henrik Clausen Albert J. R. Heck
author_facet	Tomislav Čaval Weihua Tian Zhang Yang Henrik Clausen Albert J. R. Heck
author_sort	Tomislav Čaval
title	Direct quality control of glycoengineered erythropoietin variants
title_short	Direct quality control of glycoengineered erythropoietin variants
title_full	Direct quality control of glycoengineered erythropoietin variants
title_fullStr	Direct quality control of glycoengineered erythropoietin variants
title_full_unstemmed	Direct quality control of glycoengineered erythropoietin variants
title_sort	direct quality control of glycoengineered erythropoietin variants
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6d591091bbd4425594268aada88a4112
work_keys_str_mv	AT tomislavcaval directqualitycontrolofglycoengineerederythropoietinvariants AT weihuatian directqualitycontrolofglycoengineerederythropoietinvariants AT zhangyang directqualitycontrolofglycoengineerederythropoietinvariants AT henrikclausen directqualitycontrolofglycoengineerederythropoietinvariants AT albertjrheck directqualitycontrolofglycoengineerederythropoietinvariants
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Direct quality control of glycoengineered erythropoietin variants

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