Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers.

<h4>Background and objective</h4>The risk factors for breakthrough infections among healthcare workers (HCW) after completion of a full course of vaccination are poorly understood. Our objective was to determine the risk factors for breakthrough SARS-CoV-2 infection among HCWs at a natio...

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Autores principales:	Moza Alishaq, Hanaa Nafady-Hego, Andrew Jeremijenko, Jameela Ali Al Ajmi, Mohamed Elgendy, Suni Vinoy, Sameera Bihi Fareh, Justine Veronica Plaatjies, Mariam Nooh, Nadya Alanzi, Anvar H Kaleeckal, Ali Nizar Latif, Peter Coyle, Hamed Elgendy, Abdul-Badi Abou-Samra, Adeel Ajwad Butt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d5b78f9c66b40339664856baa82b355
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spelling	oai:doaj.org-article:6d5b78f9c66b40339664856baa82b3552021-12-02T20:07:51ZRisk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers.1932-620310.1371/journal.pone.0258820https://doaj.org/article/6d5b78f9c66b40339664856baa82b3552021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258820https://doaj.org/toc/1932-6203<h4>Background and objective</h4>The risk factors for breakthrough infections among healthcare workers (HCW) after completion of a full course of vaccination are poorly understood. Our objective was to determine the risk factors for breakthrough SARS-CoV-2 infection among HCWs at a national healthcare system in Qatar.<h4>Methods</h4>We identified all HCWs at Hamad Medical Corporation in Qatar between December 20, 2020 and May 18, 2021 with confirmed SARS-CoV-2 RT-PCR infection >14 days after the second vaccine dose. For each case thus identified, we identified one control with a negative test after December 20, 2020, matched on age, sex, nationality, job family and date of SARS-CoV-2 testing. We excluded those with a prior positive test and temporary workers. We used Cox regression analysis to determine factors associated with breakthrough infection.<h4>Results</h4>Among 22,247 fully vaccinated HCW, we identified 164 HCW who had breakthrough infection and matched them to 164 controls to determine the factors associated with SARS-CoV-2 breakthrough infection. In the breakthrough infection group the nursing and midwifery job family constituted the largest group, spouse was identified as the most common positive contact followed by a patient. Exposure to a confirmed case, presence of symptoms and all other job families except Allied Health Professionals when compared with nursing and Midwifery staff independently predicted infection.<h4>Conclusion</h4>Presence of symptoms and contact with a confirmed case are major risk factors for breakthrough SARS-CoV-2 infection after vaccination, and these groups should be prioritized for screening even after full vaccination.Moza AlishaqHanaa Nafady-HegoAndrew JeremijenkoJameela Ali Al AjmiMohamed ElgendySuni VinoySameera Bihi FarehJustine Veronica PlaatjiesMariam NoohNadya AlanziAnvar H KaleeckalAli Nizar LatifPeter CoyleHamed ElgendyAbdul-Badi Abou-SamraAdeel Ajwad ButtPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258820 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Moza Alishaq Hanaa Nafady-Hego Andrew Jeremijenko Jameela Ali Al Ajmi Mohamed Elgendy Suni Vinoy Sameera Bihi Fareh Justine Veronica Plaatjies Mariam Nooh Nadya Alanzi Anvar H Kaleeckal Ali Nizar Latif Peter Coyle Hamed Elgendy Abdul-Badi Abou-Samra Adeel Ajwad Butt Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers.
description	<h4>Background and objective</h4>The risk factors for breakthrough infections among healthcare workers (HCW) after completion of a full course of vaccination are poorly understood. Our objective was to determine the risk factors for breakthrough SARS-CoV-2 infection among HCWs at a national healthcare system in Qatar.<h4>Methods</h4>We identified all HCWs at Hamad Medical Corporation in Qatar between December 20, 2020 and May 18, 2021 with confirmed SARS-CoV-2 RT-PCR infection >14 days after the second vaccine dose. For each case thus identified, we identified one control with a negative test after December 20, 2020, matched on age, sex, nationality, job family and date of SARS-CoV-2 testing. We excluded those with a prior positive test and temporary workers. We used Cox regression analysis to determine factors associated with breakthrough infection.<h4>Results</h4>Among 22,247 fully vaccinated HCW, we identified 164 HCW who had breakthrough infection and matched them to 164 controls to determine the factors associated with SARS-CoV-2 breakthrough infection. In the breakthrough infection group the nursing and midwifery job family constituted the largest group, spouse was identified as the most common positive contact followed by a patient. Exposure to a confirmed case, presence of symptoms and all other job families except Allied Health Professionals when compared with nursing and Midwifery staff independently predicted infection.<h4>Conclusion</h4>Presence of symptoms and contact with a confirmed case are major risk factors for breakthrough SARS-CoV-2 infection after vaccination, and these groups should be prioritized for screening even after full vaccination.
format	article
author	Moza Alishaq Hanaa Nafady-Hego Andrew Jeremijenko Jameela Ali Al Ajmi Mohamed Elgendy Suni Vinoy Sameera Bihi Fareh Justine Veronica Plaatjies Mariam Nooh Nadya Alanzi Anvar H Kaleeckal Ali Nizar Latif Peter Coyle Hamed Elgendy Abdul-Badi Abou-Samra Adeel Ajwad Butt
author_facet	Moza Alishaq Hanaa Nafady-Hego Andrew Jeremijenko Jameela Ali Al Ajmi Mohamed Elgendy Suni Vinoy Sameera Bihi Fareh Justine Veronica Plaatjies Mariam Nooh Nadya Alanzi Anvar H Kaleeckal Ali Nizar Latif Peter Coyle Hamed Elgendy Abdul-Badi Abou-Samra Adeel Ajwad Butt
author_sort	Moza Alishaq
title	Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers.
title_short	Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers.
title_full	Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers.
title_fullStr	Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers.
title_full_unstemmed	Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers.
title_sort	risk factors for breakthrough sars-cov-2 infection in vaccinated healthcare workers.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6d5b78f9c66b40339664856baa82b355
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Risk factors for breakthrough SARS-CoV-2 infection in vaccinated healthcare workers.

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