Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice.
<h4>Background</h4>Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet containing farmed salmon prevents or contributes to insulin...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2011
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/6d5d493f1f8a4ca088fa209e9be8a123 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:6d5d493f1f8a4ca088fa209e9be8a123 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:6d5d493f1f8a4ca088fa209e9be8a1232021-11-04T06:07:54ZChronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice.1932-620310.1371/journal.pone.0025170https://doaj.org/article/6d5d493f1f8a4ca088fa209e9be8a1232011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21966444/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet containing farmed salmon prevents or contributes to insulin resistance in mice.<h4>Methodology/principal findings</h4>Adult male C57BL/6J mice were fed control diet (C), a very high-fat diet without or with farmed Atlantic salmon fillet (VHF and VHF/S, respectively), and Western diet without or with farmed Atlantic salmon fillet (WD and WD/S, respectively). Other mice were fed VHF containing farmed salmon fillet with reduced concentrations of persistent organic pollutants (VHF/S(-POPs)). We assessed body weight gain, fat mass, insulin sensitivity, glucose tolerance, ex vivo muscle glucose uptake, performed histology and immunohistochemistry analysis, and investigated gene and protein expression. In comparison with animals fed VHF and WD, consumption of both VHF/S and WD/S exaggerated insulin resistance, visceral obesity, and glucose intolerance. In addition, the ability of insulin to stimulate Akt phosphorylation and muscle glucose uptake was impaired in mice fed farmed salmon. Relative to VHF/S-fed mice, animals fed VHF/S(-POPs) had less body burdens of POPs, accumulated less visceral fat, and had reduced mRNA levels of TNFα as well as macrophage infiltration in adipose tissue. VHF/S(-POPs)-fed mice further exhibited better insulin sensitivity and glucose tolerance than mice fed VHF/S.<h4>Conclusions/significance</h4>Our data indicate that intake of farmed salmon fillet contributes to several metabolic disorders linked to type 2 diabetes and obesity, and suggest a role of POPs in these deleterious effects. Overall, these findings may participate to improve nutritional strategies for the prevention and therapy of insulin resistance.Mohammad Madani IbrahimEven FjæreErik-Jan LockDanielle NavilleHeidi AmlundEmmanuelle MeugnierBrigitte Le Magueresse BattistoniLivar FrøylandLise MadsenNiels JessenSten LundHubert VidalJérôme RuzzinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e25170 (2011) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Mohammad Madani Ibrahim Even Fjære Erik-Jan Lock Danielle Naville Heidi Amlund Emmanuelle Meugnier Brigitte Le Magueresse Battistoni Livar Frøyland Lise Madsen Niels Jessen Sten Lund Hubert Vidal Jérôme Ruzzin Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. |
| description |
<h4>Background</h4>Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet containing farmed salmon prevents or contributes to insulin resistance in mice.<h4>Methodology/principal findings</h4>Adult male C57BL/6J mice were fed control diet (C), a very high-fat diet without or with farmed Atlantic salmon fillet (VHF and VHF/S, respectively), and Western diet without or with farmed Atlantic salmon fillet (WD and WD/S, respectively). Other mice were fed VHF containing farmed salmon fillet with reduced concentrations of persistent organic pollutants (VHF/S(-POPs)). We assessed body weight gain, fat mass, insulin sensitivity, glucose tolerance, ex vivo muscle glucose uptake, performed histology and immunohistochemistry analysis, and investigated gene and protein expression. In comparison with animals fed VHF and WD, consumption of both VHF/S and WD/S exaggerated insulin resistance, visceral obesity, and glucose intolerance. In addition, the ability of insulin to stimulate Akt phosphorylation and muscle glucose uptake was impaired in mice fed farmed salmon. Relative to VHF/S-fed mice, animals fed VHF/S(-POPs) had less body burdens of POPs, accumulated less visceral fat, and had reduced mRNA levels of TNFα as well as macrophage infiltration in adipose tissue. VHF/S(-POPs)-fed mice further exhibited better insulin sensitivity and glucose tolerance than mice fed VHF/S.<h4>Conclusions/significance</h4>Our data indicate that intake of farmed salmon fillet contributes to several metabolic disorders linked to type 2 diabetes and obesity, and suggest a role of POPs in these deleterious effects. Overall, these findings may participate to improve nutritional strategies for the prevention and therapy of insulin resistance. |
| format |
article |
| author |
Mohammad Madani Ibrahim Even Fjære Erik-Jan Lock Danielle Naville Heidi Amlund Emmanuelle Meugnier Brigitte Le Magueresse Battistoni Livar Frøyland Lise Madsen Niels Jessen Sten Lund Hubert Vidal Jérôme Ruzzin |
| author_facet |
Mohammad Madani Ibrahim Even Fjære Erik-Jan Lock Danielle Naville Heidi Amlund Emmanuelle Meugnier Brigitte Le Magueresse Battistoni Livar Frøyland Lise Madsen Niels Jessen Sten Lund Hubert Vidal Jérôme Ruzzin |
| author_sort |
Mohammad Madani Ibrahim |
| title |
Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. |
| title_short |
Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. |
| title_full |
Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. |
| title_fullStr |
Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. |
| title_full_unstemmed |
Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. |
| title_sort |
chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/6d5d493f1f8a4ca088fa209e9be8a123 |
| work_keys_str_mv |
AT mohammadmadaniibrahim chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT evenfjære chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT erikjanlock chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT daniellenaville chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT heidiamlund chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT emmanuellemeugnier chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT brigittelemagueressebattistoni chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT livarfrøyland chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT lisemadsen chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT nielsjessen chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT stenlund chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT hubertvidal chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice AT jeromeruzzin chronicconsumptionoffarmedsalmoncontainingpersistentorganicpollutantscausesinsulinresistanceandobesityinmice |
| _version_ |
1718445154165063680 |