Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

Mitochondria are a source of reactive oxygen species, which can be exploited to induce the death of cancer cells. Here, the authors use nanoparticles that release camptothecin in a reactive oxygen species dependent manner, leading to cancer cell death.

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Detalles Bibliográficos
Autores principales:	Wenjia Zhang, Xianglong Hu, Qi Shen, Da Xing
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d5da74a11b647ee870c25a0246705d3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:6d5da74a11b647ee870c25a0246705d32021-12-02T17:02:00ZMitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy10.1038/s41467-019-09566-32041-1723https://doaj.org/article/6d5da74a11b647ee870c25a0246705d32019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09566-3https://doaj.org/toc/2041-1723Mitochondria are a source of reactive oxygen species, which can be exploited to induce the death of cancer cells. Here, the authors use nanoparticles that release camptothecin in a reactive oxygen species dependent manner, leading to cancer cell death.Wenjia ZhangXianglong HuQi ShenDa XingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenjia Zhang Xianglong Hu Qi Shen Da Xing Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy
description	Mitochondria are a source of reactive oxygen species, which can be exploited to induce the death of cancer cells. Here, the authors use nanoparticles that release camptothecin in a reactive oxygen species dependent manner, leading to cancer cell death.
format	article
author	Wenjia Zhang Xianglong Hu Qi Shen Da Xing
author_facet	Wenjia Zhang Xianglong Hu Qi Shen Da Xing
author_sort	Wenjia Zhang
title	Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy
title_short	Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy
title_full	Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy
title_fullStr	Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy
title_full_unstemmed	Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy
title_sort	mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6d5da74a11b647ee870c25a0246705d3
work_keys_str_mv	AT wenjiazhang mitochondriaspecificdrugreleaseandreactiveoxygenspeciesburstinducedbypolyprodrugnanoreactorscanenhancechemotherapy AT xianglonghu mitochondriaspecificdrugreleaseandreactiveoxygenspeciesburstinducedbypolyprodrugnanoreactorscanenhancechemotherapy AT qishen mitochondriaspecificdrugreleaseandreactiveoxygenspeciesburstinducedbypolyprodrugnanoreactorscanenhancechemotherapy AT daxing mitochondriaspecificdrugreleaseandreactiveoxygenspeciesburstinducedbypolyprodrugnanoreactorscanenhancechemotherapy
_version_	1718381973493252096

Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

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