Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies

Effat Sadat Farboud, Saman Ahmad Nasrollahi, Zahra TabbakhiDepartment of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, IranAbstract: Solid lipid nanoparticles (SLNs) of coenzyme Q10 (CoQ10) were formulated by a high-pressure homogenization method. The best formula...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Farboud ES, Nasrollahi SA, Tabbakhi Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6d5e2946bddc4e7b9891956e866e98e9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6d5e2946bddc4e7b9891956e866e98e9
record_format	dspace
spelling	oai:doaj.org-article:6d5e2946bddc4e7b9891956e866e98e92021-12-02T00:54:48ZNovel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies1176-91141178-2013https://doaj.org/article/6d5e2946bddc4e7b9891956e866e98e92011-03-01T00:00:00Zhttp://www.dovepress.com/novel-formulation-and-evaluation-of-a-q10-loaded-solid-lipid-nanoparti-a6889https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Effat Sadat Farboud, Saman Ahmad Nasrollahi, Zahra TabbakhiDepartment of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, IranAbstract: Solid lipid nanoparticles (SLNs) of coenzyme Q10 (CoQ10) were formulated by a high-pressure homogenization method. The best formulation of SLN dispersion consisted of 13% lipid (cetyl palmitate or stearic acid), 8% surfactant (Tween 80 or Tego Care 450), and water. Stability tests, particle size analysis, differential scanning calorimetry, transmission electron microscopy, and release study were conducted to find the best formulation. A simple cream of CoQ10 and a cream containing CoQ10-loaded SLNs were prepared and compared on volunteers aged 20&ndash;30 years. SLNs with particle size between 50 nm and100 nm exhibited the most suitable stability. In vitro release profiles of CoQ10 from simple cream, SLN alone, and CoQ10-loaded SLN cream showed prolonged release for SLNs compared with the simple cream, whereas there was no significant difference between SLN alone and SLN in cream. In vitro release studies also demonstrated that CoQ10-loaded SLN and SLN cream possessed a biphasic release pattern in comparison with simple cream. In vivo skin hydration and elasticity studies on 25 volunteers suggested good dermal penetration and useful activity of Q10 on skin as a hydratant and antiwrinkle cream.Keywords: coenzyme Q10, SLN, release study&nbsp; Farboud ESNasrollahi SATabbakhi ZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 611-617 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Farboud ES Nasrollahi SA Tabbakhi Z Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies
description	Effat Sadat Farboud, Saman Ahmad Nasrollahi, Zahra TabbakhiDepartment of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, IranAbstract: Solid lipid nanoparticles (SLNs) of coenzyme Q10 (CoQ10) were formulated by a high-pressure homogenization method. The best formulation of SLN dispersion consisted of 13% lipid (cetyl palmitate or stearic acid), 8% surfactant (Tween 80 or Tego Care 450), and water. Stability tests, particle size analysis, differential scanning calorimetry, transmission electron microscopy, and release study were conducted to find the best formulation. A simple cream of CoQ10 and a cream containing CoQ10-loaded SLNs were prepared and compared on volunteers aged 20&ndash;30 years. SLNs with particle size between 50 nm and100 nm exhibited the most suitable stability. In vitro release profiles of CoQ10 from simple cream, SLN alone, and CoQ10-loaded SLN cream showed prolonged release for SLNs compared with the simple cream, whereas there was no significant difference between SLN alone and SLN in cream. In vitro release studies also demonstrated that CoQ10-loaded SLN and SLN cream possessed a biphasic release pattern in comparison with simple cream. In vivo skin hydration and elasticity studies on 25 volunteers suggested good dermal penetration and useful activity of Q10 on skin as a hydratant and antiwrinkle cream.Keywords: coenzyme Q10, SLN, release study&nbsp;
format	article
author	Farboud ES Nasrollahi SA Tabbakhi Z
author_facet	Farboud ES Nasrollahi SA Tabbakhi Z
author_sort	Farboud ES
title	Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies
title_short	Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies
title_full	Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies
title_fullStr	Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies
title_full_unstemmed	Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies
title_sort	novel formulation and evaluation of a q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/6d5e2946bddc4e7b9891956e866e98e9
work_keys_str_mv	AT farboudes novelformulationandevaluationofaq10loadedsolidlipidnanoparticlecreaminvitroandinvivostudies AT nasrollahisa novelformulationandevaluationofaq10loadedsolidlipidnanoparticlecreaminvitroandinvivostudies AT tabbakhiz novelformulationandevaluationofaq10loadedsolidlipidnanoparticlecreaminvitroandinvivostudies
_version_	1718403390297341952

Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies

Ejemplares similares