Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid.

Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid.

Caspase-8 is involved in death receptor-mediated apoptosis in type II cells, the proapoptotic programme of which is triggered by truncated Bid. Indeed, caspase-8 and Bid are the known intermediates of this signalling pathway. Cardiolipin has been shown to provide an anchor and an essential activatin...

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Main Authors: Olivier Jalmar, Liberty François-Moutal, Ana-Jesus García-Sáez, Mark Perry, Thierry Granjon, François Gonzalvez, Eyal Gottlieb, Jesus Ayala-Sanmartin, Beate Klösgen, Petra Schwille, Patrice X Petit
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/6d5e3f822fb745eca6f2cbe1fbf38d5e
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