Chlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility

Abstract Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection. However, whether Chlamydia trachomatis has a negative impact on sperm quality and male fertility is still controversial. Herein, we report the effects on sperm quality of the in vitro exposure of spermatoz...

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Autores principales:	Jenniffer Puerta Suarez, Leonardo R. Sanchez, Florencia C. Salazar, Hector A. Saka, Rosa Molina, Andrea Tissera, Virginia E. Rivero, Walter D. Cardona Maya, Ruben D. Motrich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d61bf49b78e40db8de3cc82ca97f355
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spelling	oai:doaj.org-article:6d61bf49b78e40db8de3cc82ca97f3552021-12-02T11:52:18ZChlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility10.1038/s41598-017-01262-w2045-2322https://doaj.org/article/6d61bf49b78e40db8de3cc82ca97f3552017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01262-whttps://doaj.org/toc/2045-2322Abstract Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection. However, whether Chlamydia trachomatis has a negative impact on sperm quality and male fertility is still controversial. Herein, we report the effects on sperm quality of the in vitro exposure of spermatozoa to Chlamydia trachomatis, and also the effects of male genital infection on male fertility using an animal model. Human and mouse sperm were obtained from healthy donors and cauda epididimys from C57BL/6 mice, respectively. Highly motile human or mouse spermatozoa were in vitro exposed to C. trachomatis (serovar E or LGV) or C. muridarum, respectively. Then, sperm quality parameters were analyzed. Moreover, male fertility of Chlamydia muridarum infected male C57BL/6 mice was assessed. Human or murine sperm in vitro exposed to increasing bacterial concentrations or soluble factors from C. trachomatis or C. muridarum, respectively, did not show differences in sperm motility and viability, apoptosis, mitochondrial membrane potential, DNA fragmentation, ROS production and lipid peroxidation levels, when compared with control sperm (p > 0.05). Moreover, no differences in fertility parameters (potency, fecundity, fertility index, pre- and post-implantation loss) were observed between control and infected males. In conclusion, our results indicate that Chlamydia spp. neither directly exerts deleterious effects on spermatozoa nor impairs male fertility.Jenniffer Puerta SuarezLeonardo R. SanchezFlorencia C. SalazarHector A. SakaRosa MolinaAndrea TisseraVirginia E. RiveroWalter D. Cardona MayaRuben D. MotrichNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jenniffer Puerta Suarez Leonardo R. Sanchez Florencia C. Salazar Hector A. Saka Rosa Molina Andrea Tissera Virginia E. Rivero Walter D. Cardona Maya Ruben D. Motrich Chlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility
description	Abstract Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection. However, whether Chlamydia trachomatis has a negative impact on sperm quality and male fertility is still controversial. Herein, we report the effects on sperm quality of the in vitro exposure of spermatozoa to Chlamydia trachomatis, and also the effects of male genital infection on male fertility using an animal model. Human and mouse sperm were obtained from healthy donors and cauda epididimys from C57BL/6 mice, respectively. Highly motile human or mouse spermatozoa were in vitro exposed to C. trachomatis (serovar E or LGV) or C. muridarum, respectively. Then, sperm quality parameters were analyzed. Moreover, male fertility of Chlamydia muridarum infected male C57BL/6 mice was assessed. Human or murine sperm in vitro exposed to increasing bacterial concentrations or soluble factors from C. trachomatis or C. muridarum, respectively, did not show differences in sperm motility and viability, apoptosis, mitochondrial membrane potential, DNA fragmentation, ROS production and lipid peroxidation levels, when compared with control sperm (p > 0.05). Moreover, no differences in fertility parameters (potency, fecundity, fertility index, pre- and post-implantation loss) were observed between control and infected males. In conclusion, our results indicate that Chlamydia spp. neither directly exerts deleterious effects on spermatozoa nor impairs male fertility.
format	article
author	Jenniffer Puerta Suarez Leonardo R. Sanchez Florencia C. Salazar Hector A. Saka Rosa Molina Andrea Tissera Virginia E. Rivero Walter D. Cardona Maya Ruben D. Motrich
author_facet	Jenniffer Puerta Suarez Leonardo R. Sanchez Florencia C. Salazar Hector A. Saka Rosa Molina Andrea Tissera Virginia E. Rivero Walter D. Cardona Maya Ruben D. Motrich
author_sort	Jenniffer Puerta Suarez
title	Chlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility
title_short	Chlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility
title_full	Chlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility
title_fullStr	Chlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility
title_full_unstemmed	Chlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility
title_sort	chlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6d61bf49b78e40db8de3cc82ca97f355
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Chlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility

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