Myriocin significantly increases the mortality of a non-mammalian model host during Candida pathogenesis.
Candida albicans is a major human pathogen whose treatment is challenging due to antifungal drug toxicity, drug resistance and paucity of antifungal agents available. Myrocin (MYR) inhibits sphingosine synthesis, a precursor of sphingolipids, an important cell membrane and signaling molecule compone...
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Auteurs principaux: | Nadja Rodrigues de Melo, Ahmed Abdrahman, Carolyn Greig, Krishnendu Mukherjee, Catherine Thornton, Norman A Ratcliffe, Andreas Vilcinskas, Tariq M Butt |
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Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2013
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Accès en ligne: | https://doaj.org/article/6d66e5047bb547e09bedfbf2992af3a7 |
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