A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus

Genetic screens are important tools to identify host factors associated with viral infections. Here, Flint et al. perform a genome-wide CRISPR screen using infectious Ebola virus (EBOV) and show that the host transferase GNPTAB is required for EBOV infection and a potential target for antiviral ther...

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Autores principales:	Mike Flint, Payel Chatterjee, David L. Lin, Laura K. McMullan, Punya Shrivastava-Ranjan, Éric Bergeron, Michael K. Lo, Stephen R. Welch, Stuart T. Nichol, Andrew W. Tai, Christina F. Spiropoulou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d67096f29cf459880d85fa3e0fe6a72
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spelling	oai:doaj.org-article:6d67096f29cf459880d85fa3e0fe6a722021-12-02T14:39:16ZA genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus10.1038/s41467-018-08135-42041-1723https://doaj.org/article/6d67096f29cf459880d85fa3e0fe6a722019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08135-4https://doaj.org/toc/2041-1723Genetic screens are important tools to identify host factors associated with viral infections. Here, Flint et al. perform a genome-wide CRISPR screen using infectious Ebola virus (EBOV) and show that the host transferase GNPTAB is required for EBOV infection and a potential target for antiviral therapiesMike FlintPayel ChatterjeeDavid L. LinLaura K. McMullanPunya Shrivastava-RanjanÉric BergeronMichael K. LoStephen R. WelchStuart T. NicholAndrew W. TaiChristina F. SpiropoulouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mike Flint Payel Chatterjee David L. Lin Laura K. McMullan Punya Shrivastava-Ranjan Éric Bergeron Michael K. Lo Stephen R. Welch Stuart T. Nichol Andrew W. Tai Christina F. Spiropoulou A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus
description	Genetic screens are important tools to identify host factors associated with viral infections. Here, Flint et al. perform a genome-wide CRISPR screen using infectious Ebola virus (EBOV) and show that the host transferase GNPTAB is required for EBOV infection and a potential target for antiviral therapies
format	article
author	Mike Flint Payel Chatterjee David L. Lin Laura K. McMullan Punya Shrivastava-Ranjan Éric Bergeron Michael K. Lo Stephen R. Welch Stuart T. Nichol Andrew W. Tai Christina F. Spiropoulou
author_facet	Mike Flint Payel Chatterjee David L. Lin Laura K. McMullan Punya Shrivastava-Ranjan Éric Bergeron Michael K. Lo Stephen R. Welch Stuart T. Nichol Andrew W. Tai Christina F. Spiropoulou
author_sort	Mike Flint
title	A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus
title_short	A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus
title_full	A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus
title_fullStr	A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus
title_full_unstemmed	A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus
title_sort	genome-wide crispr screen identifies n-acetylglucosamine-1-phosphate transferase as a potential antiviral target for ebola virus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6d67096f29cf459880d85fa3e0fe6a72
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A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus

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