A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns and preventing premature termination of multiple tr...

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Autores principales: Yaroslav A. Kainov, Eugene V. Makeyev
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/6d704b112a6f4d6cbb4e7b72ad4628ff
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spelling oai:doaj.org-article:6d704b112a6f4d6cbb4e7b72ad4628ff2021-12-02T14:41:03ZA transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells10.1038/s41467-019-14204-z2041-1723https://doaj.org/article/6d704b112a6f4d6cbb4e7b72ad4628ff2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14204-zhttps://doaj.org/toc/2041-1723Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns and preventing premature termination of multiple transcripts.Yaroslav A. KainovEugene V. MakeyevNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yaroslav A. Kainov
Eugene V. Makeyev
A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
description Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns and preventing premature termination of multiple transcripts.
format article
author Yaroslav A. Kainov
Eugene V. Makeyev
author_facet Yaroslav A. Kainov
Eugene V. Makeyev
author_sort Yaroslav A. Kainov
title A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
title_short A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
title_full A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
title_fullStr A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
title_full_unstemmed A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
title_sort transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/6d704b112a6f4d6cbb4e7b72ad4628ff
work_keys_str_mv AT yaroslavakainov atranscriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells
AT eugenevmakeyev atranscriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells
AT yaroslavakainov transcriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells
AT eugenevmakeyev transcriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells
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