A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns and preventing premature termination of multiple tr...

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Autores principales:	Yaroslav A. Kainov, Eugene V. Makeyev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d704b112a6f4d6cbb4e7b72ad4628ff
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spelling	oai:doaj.org-article:6d704b112a6f4d6cbb4e7b72ad4628ff2021-12-02T14:41:03ZA transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells10.1038/s41467-019-14204-z2041-1723https://doaj.org/article/6d704b112a6f4d6cbb4e7b72ad4628ff2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14204-zhttps://doaj.org/toc/2041-1723Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns and preventing premature termination of multiple transcripts.Yaroslav A. KainovEugene V. MakeyevNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yaroslav A. Kainov Eugene V. Makeyev A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
description	Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns and preventing premature termination of multiple transcripts.
format	article
author	Yaroslav A. Kainov Eugene V. Makeyev
author_facet	Yaroslav A. Kainov Eugene V. Makeyev
author_sort	Yaroslav A. Kainov
title	A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
title_short	A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
title_full	A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
title_fullStr	A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
title_full_unstemmed	A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
title_sort	transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6d704b112a6f4d6cbb4e7b72ad4628ff
work_keys_str_mv	AT yaroslavakainov atranscriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells AT eugenevmakeyev atranscriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells AT yaroslavakainov transcriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells AT eugenevmakeyev transcriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells
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A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

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