A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns and preventing premature termination of multiple tr...
Guardado en:
Autores principales: | , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/6d704b112a6f4d6cbb4e7b72ad4628ff |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:6d704b112a6f4d6cbb4e7b72ad4628ff |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:6d704b112a6f4d6cbb4e7b72ad4628ff2021-12-02T14:41:03ZA transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells10.1038/s41467-019-14204-z2041-1723https://doaj.org/article/6d704b112a6f4d6cbb4e7b72ad4628ff2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14204-zhttps://doaj.org/toc/2041-1723Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns and preventing premature termination of multiple transcripts.Yaroslav A. KainovEugene V. MakeyevNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Yaroslav A. Kainov Eugene V. Makeyev A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells |
description |
Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns and preventing premature termination of multiple transcripts. |
format |
article |
author |
Yaroslav A. Kainov Eugene V. Makeyev |
author_facet |
Yaroslav A. Kainov Eugene V. Makeyev |
author_sort |
Yaroslav A. Kainov |
title |
A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells |
title_short |
A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells |
title_full |
A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells |
title_fullStr |
A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells |
title_full_unstemmed |
A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells |
title_sort |
transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/6d704b112a6f4d6cbb4e7b72ad4628ff |
work_keys_str_mv |
AT yaroslavakainov atranscriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells AT eugenevmakeyev atranscriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells AT yaroslavakainov transcriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells AT eugenevmakeyev transcriptomewideantiterminationmechanismsustainingidentityofembryonicstemcells |
_version_ |
1718390058077126656 |