A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns and preventing premature termination of multiple tr...

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Autores principales: Yaroslav A. Kainov, Eugene V. Makeyev
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/6d704b112a6f4d6cbb4e7b72ad4628ff
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