Genetic variants linked to T2DM risk in Kurdish populations

Shadi Golsheh,1 Fatemeh Keshavarzi21Department of Biology, Kurdistan Science and Research Branch, Islamic Azad University, Sanandaj, Iran; 2Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, IranBackground: The polymorphisms of the C–C chemokine receptor type 5 (CCR...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Golsheh S, Keshavarzi F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	IRS1 (rs10498210) CCR5 (59029A/G) Type 2 diabetes Kurdish patients Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/6d71b290b6fc4dfe87d7f0a95dc50d2e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6d71b290b6fc4dfe87d7f0a95dc50d2e
record_format	dspace
spelling	oai:doaj.org-article:6d71b290b6fc4dfe87d7f0a95dc50d2e2021-12-02T09:58:13ZGenetic variants linked to T2DM risk in Kurdish populations1178-7007https://doaj.org/article/6d71b290b6fc4dfe87d7f0a95dc50d2e2019-04-01T00:00:00Zhttps://www.dovepress.com/genetic-variants-linked-to-t2dm-risk-in-kurdish-populations-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Shadi Golsheh,1 Fatemeh Keshavarzi21Department of Biology, Kurdistan Science and Research Branch, Islamic Azad University, Sanandaj, Iran; 2Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, IranBackground: The polymorphisms of the C–C chemokine receptor type 5 (CCR5) and the insulin receptor substrate 1 (IRS1) have been studied as candidates for the susceptibility to develop type 2 diabetes mellitus (T2DM). CCR5 is a chemokine receptor, and the polymorphisms in the promoter region of this receptor are being studied as candidates for the susceptibility to develop T2DM. Also, IRS1 is a critical factor in the signaling pathway for insulin, and mutations in this gene have been reported, which contribute to the ability to develop T2DM. The aim of the current study was to determine the relationship between CCR5 (59029A/G) and IRS1 (rs10498210) polymorphisms with T2DM in Sanandajian patients.Methods: Genomic DNA was isolated from 200 healthy individuals and 220 Kurdish T2DM patients by salt extraction method and the polymorphisms were examined by restriction fragment length polymorphism (RFLP) method and then the results were analyzed using Chi-square test.Results: The frequency of AA genotype in 220 Kurdish patients for both genes CCR5 (OR=1.9, P=0.02) and IRS1 (OR [95% CI]=2.62, P=0.02) were significantly more than controls. There was no significant association between AG or GG genotypes in with T2DM.Conclusion: The presence of AA homozygote alleles in both loci of IRS1 (rs10498210) and CCR5 (59029A/G) genes increased the risk of T2DM.Keywords: IRS1 (rs10498210), CCR5 (59029A/G), type 2 diabetes, Kurdish patientsGolsheh SKeshavarzi FDove Medical PressarticleIRS1 (rs10498210)CCR5 (59029A/G)Type 2 diabetesKurdish patientsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 431-437 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	IRS1 (rs10498210) CCR5 (59029A/G) Type 2 diabetes Kurdish patients Specialties of internal medicine RC581-951
spellingShingle	IRS1 (rs10498210) CCR5 (59029A/G) Type 2 diabetes Kurdish patients Specialties of internal medicine RC581-951 Golsheh S Keshavarzi F Genetic variants linked to T2DM risk in Kurdish populations
description	Shadi Golsheh,1 Fatemeh Keshavarzi21Department of Biology, Kurdistan Science and Research Branch, Islamic Azad University, Sanandaj, Iran; 2Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, IranBackground: The polymorphisms of the C–C chemokine receptor type 5 (CCR5) and the insulin receptor substrate 1 (IRS1) have been studied as candidates for the susceptibility to develop type 2 diabetes mellitus (T2DM). CCR5 is a chemokine receptor, and the polymorphisms in the promoter region of this receptor are being studied as candidates for the susceptibility to develop T2DM. Also, IRS1 is a critical factor in the signaling pathway for insulin, and mutations in this gene have been reported, which contribute to the ability to develop T2DM. The aim of the current study was to determine the relationship between CCR5 (59029A/G) and IRS1 (rs10498210) polymorphisms with T2DM in Sanandajian patients.Methods: Genomic DNA was isolated from 200 healthy individuals and 220 Kurdish T2DM patients by salt extraction method and the polymorphisms were examined by restriction fragment length polymorphism (RFLP) method and then the results were analyzed using Chi-square test.Results: The frequency of AA genotype in 220 Kurdish patients for both genes CCR5 (OR=1.9, P=0.02) and IRS1 (OR [95% CI]=2.62, P=0.02) were significantly more than controls. There was no significant association between AG or GG genotypes in with T2DM.Conclusion: The presence of AA homozygote alleles in both loci of IRS1 (rs10498210) and CCR5 (59029A/G) genes increased the risk of T2DM.Keywords: IRS1 (rs10498210), CCR5 (59029A/G), type 2 diabetes, Kurdish patients
format	article
author	Golsheh S Keshavarzi F
author_facet	Golsheh S Keshavarzi F
author_sort	Golsheh S
title	Genetic variants linked to T2DM risk in Kurdish populations
title_short	Genetic variants linked to T2DM risk in Kurdish populations
title_full	Genetic variants linked to T2DM risk in Kurdish populations
title_fullStr	Genetic variants linked to T2DM risk in Kurdish populations
title_full_unstemmed	Genetic variants linked to T2DM risk in Kurdish populations
title_sort	genetic variants linked to t2dm risk in kurdish populations
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/6d71b290b6fc4dfe87d7f0a95dc50d2e
work_keys_str_mv	AT golshehs geneticvariantslinkedtot2dmriskinkurdishpopulations AT keshavarzif geneticvariantslinkedtot2dmriskinkurdishpopulations
_version_	1718397886683676672

Genetic variants linked to T2DM risk in Kurdish populations

Ejemplares similares