A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery

Munson et al. develop a high-throughput Galectin-9 reporter based endosomal escape imaging assay to probe correlations between nanoparticle-mediated uptake, endosomal escape frequency, and mRNA translation. By screening various delivery systems, modulators and combinations of nanoparticle components...

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Autores principales: Michael J. Munson, Gwen O’Driscoll, Andreia M. Silva, Elisa Lázaro-Ibáñez, Audrey Gallud, John T. Wilson, Anna Collén, Elin K. Esbjörner, Alan Sabirsh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6d71f1a55da4454e8e456d8390871e01
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