Functional ultrasound imaging: A useful tool for functional connectomics?

Functional ultrasound (fUS) is a hemodynamic-based functional neuroimaging technique, primarily used in animal models, that combines a high spatiotemporal resolution, a large field of view, and compatibility with behavior. These assets make fUS especially suited to interrogating brain activity at th...

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Autores principales:	Jose Maria Martinez de Paz, Emilie Macé
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Functional ultrasound imaging Brain-wide networks Functional connectivity Dynamic functional connectivity Neuroimaging Systems neuroscience Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/6d72f1ac02a24f288a0765145bbf7cc8
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spelling	oai:doaj.org-article:6d72f1ac02a24f288a0765145bbf7cc82021-11-28T04:29:01ZFunctional ultrasound imaging: A useful tool for functional connectomics?1095-957210.1016/j.neuroimage.2021.118722https://doaj.org/article/6d72f1ac02a24f288a0765145bbf7cc82021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921009940https://doaj.org/toc/1095-9572Functional ultrasound (fUS) is a hemodynamic-based functional neuroimaging technique, primarily used in animal models, that combines a high spatiotemporal resolution, a large field of view, and compatibility with behavior. These assets make fUS especially suited to interrogating brain activity at the systems level. In this review, we describe the technical capabilities offered by fUS and discuss how this technique can contribute to the field of functional connectomics. First, fUS can be used to study intrinsic functional connectivity, namely patterns of correlated activity between brain regions. In this area, fUS has made the most impact by following connectivity changes in disease models, across behavioral states, or dynamically. Second, fUS can also be used to map brain-wide pathways associated with an external event. For example, fUS has helped obtain finer descriptions of several sensory systems, and uncover new pathways implicated in specific behaviors. Additionally, combining fUS with direct circuit manipulations such as optogenetics is an attractive way to map the brain-wide connections of defined neuronal populations. Finally, technological improvements and the application of new analytical tools promise to boost fUS capabilities. As brain coverage and the range of behavioral contexts that can be addressed with fUS keep on increasing, we believe that fUS-guided connectomics will only expand in the future. In this regard, we consider the incorporation of fUS into multimodal studies combining diverse techniques and behavioral tasks to be the most promising research avenue.Jose Maria Martinez de PazEmilie MacéElsevierarticleFunctional ultrasound imagingBrain-wide networksFunctional connectivityDynamic functional connectivityNeuroimagingSystems neuroscienceNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118722- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Functional ultrasound imaging Brain-wide networks Functional connectivity Dynamic functional connectivity Neuroimaging Systems neuroscience Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Functional ultrasound imaging Brain-wide networks Functional connectivity Dynamic functional connectivity Neuroimaging Systems neuroscience Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jose Maria Martinez de Paz Emilie Macé Functional ultrasound imaging: A useful tool for functional connectomics?
description	Functional ultrasound (fUS) is a hemodynamic-based functional neuroimaging technique, primarily used in animal models, that combines a high spatiotemporal resolution, a large field of view, and compatibility with behavior. These assets make fUS especially suited to interrogating brain activity at the systems level. In this review, we describe the technical capabilities offered by fUS and discuss how this technique can contribute to the field of functional connectomics. First, fUS can be used to study intrinsic functional connectivity, namely patterns of correlated activity between brain regions. In this area, fUS has made the most impact by following connectivity changes in disease models, across behavioral states, or dynamically. Second, fUS can also be used to map brain-wide pathways associated with an external event. For example, fUS has helped obtain finer descriptions of several sensory systems, and uncover new pathways implicated in specific behaviors. Additionally, combining fUS with direct circuit manipulations such as optogenetics is an attractive way to map the brain-wide connections of defined neuronal populations. Finally, technological improvements and the application of new analytical tools promise to boost fUS capabilities. As brain coverage and the range of behavioral contexts that can be addressed with fUS keep on increasing, we believe that fUS-guided connectomics will only expand in the future. In this regard, we consider the incorporation of fUS into multimodal studies combining diverse techniques and behavioral tasks to be the most promising research avenue.
format	article
author	Jose Maria Martinez de Paz Emilie Macé
author_facet	Jose Maria Martinez de Paz Emilie Macé
author_sort	Jose Maria Martinez de Paz
title	Functional ultrasound imaging: A useful tool for functional connectomics?
title_short	Functional ultrasound imaging: A useful tool for functional connectomics?
title_full	Functional ultrasound imaging: A useful tool for functional connectomics?
title_fullStr	Functional ultrasound imaging: A useful tool for functional connectomics?
title_full_unstemmed	Functional ultrasound imaging: A useful tool for functional connectomics?
title_sort	functional ultrasound imaging: a useful tool for functional connectomics?
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6d72f1ac02a24f288a0765145bbf7cc8
work_keys_str_mv	AT josemariamartinezdepaz functionalultrasoundimagingausefultoolforfunctionalconnectomics AT emiliemace functionalultrasoundimagingausefultoolforfunctionalconnectomics
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Functional ultrasound imaging: A useful tool for functional connectomics?

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