Exact firing time statistics of neurons driven by discrete inhibitory noise

Abstract Neurons in the intact brain receive a continuous and irregular synaptic bombardment from excitatory and inhibitory pre- synaptic neurons, which determines the firing activity of the stimulated neuron. In order to investigate the influence of inhibitory stimulation on the firing time statist...

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Autores principales:	Simona Olmi, David Angulo-Garcia, Alberto Imparato, Alessandro Torcini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d77eb69e75847ef952f4c6e4a5df36d
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spelling	oai:doaj.org-article:6d77eb69e75847ef952f4c6e4a5df36d2021-12-02T16:07:58ZExact firing time statistics of neurons driven by discrete inhibitory noise10.1038/s41598-017-01658-82045-2322https://doaj.org/article/6d77eb69e75847ef952f4c6e4a5df36d2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01658-8https://doaj.org/toc/2045-2322Abstract Neurons in the intact brain receive a continuous and irregular synaptic bombardment from excitatory and inhibitory pre- synaptic neurons, which determines the firing activity of the stimulated neuron. In order to investigate the influence of inhibitory stimulation on the firing time statistics, we consider Leaky Integrate-and-Fire neurons subject to inhibitory instantaneous post- synaptic potentials. In particular, we report exact results for the firing rate, the coefficient of variation and the spike train spectrum for various synaptic weight distributions. Our results are not limited to stimulations of infinitesimal amplitude, but they apply as well to finite amplitude post-synaptic potentials, thus being able to capture the effect of rare and large spikes. The developed methods are able to reproduce also the average firing properties of heterogeneous neuronal populations.Simona OlmiDavid Angulo-GarciaAlberto ImparatoAlessandro TorciniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simona Olmi David Angulo-Garcia Alberto Imparato Alessandro Torcini Exact firing time statistics of neurons driven by discrete inhibitory noise
description	Abstract Neurons in the intact brain receive a continuous and irregular synaptic bombardment from excitatory and inhibitory pre- synaptic neurons, which determines the firing activity of the stimulated neuron. In order to investigate the influence of inhibitory stimulation on the firing time statistics, we consider Leaky Integrate-and-Fire neurons subject to inhibitory instantaneous post- synaptic potentials. In particular, we report exact results for the firing rate, the coefficient of variation and the spike train spectrum for various synaptic weight distributions. Our results are not limited to stimulations of infinitesimal amplitude, but they apply as well to finite amplitude post-synaptic potentials, thus being able to capture the effect of rare and large spikes. The developed methods are able to reproduce also the average firing properties of heterogeneous neuronal populations.
format	article
author	Simona Olmi David Angulo-Garcia Alberto Imparato Alessandro Torcini
author_facet	Simona Olmi David Angulo-Garcia Alberto Imparato Alessandro Torcini
author_sort	Simona Olmi
title	Exact firing time statistics of neurons driven by discrete inhibitory noise
title_short	Exact firing time statistics of neurons driven by discrete inhibitory noise
title_full	Exact firing time statistics of neurons driven by discrete inhibitory noise
title_fullStr	Exact firing time statistics of neurons driven by discrete inhibitory noise
title_full_unstemmed	Exact firing time statistics of neurons driven by discrete inhibitory noise
title_sort	exact firing time statistics of neurons driven by discrete inhibitory noise
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6d77eb69e75847ef952f4c6e4a5df36d
work_keys_str_mv	AT simonaolmi exactfiringtimestatisticsofneuronsdrivenbydiscreteinhibitorynoise AT davidangulogarcia exactfiringtimestatisticsofneuronsdrivenbydiscreteinhibitorynoise AT albertoimparato exactfiringtimestatisticsofneuronsdrivenbydiscreteinhibitorynoise AT alessandrotorcini exactfiringtimestatisticsofneuronsdrivenbydiscreteinhibitorynoise
_version_	1718384662651338752

Exact firing time statistics of neurons driven by discrete inhibitory noise

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