Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.

<h4>Background</h4>Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease involving upper and lower motor neurons loss. Clinical features are highly variable among patients and there are currently few known disease-modifying factors underlying this heterogene...

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Autores principales:	Luc Dupuis, Odile Spreux-Varoquaux, Gilbert Bensimon, Philippe Jullien, Lucette Lacomblez, François Salachas, Gaëlle Bruneteau, Pierre-François Pradat, Jean-Philippe Loeffler, Vincent Meininger
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d79b37c074f418c8d2e8f6600ba01a4
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spelling	oai:doaj.org-article:6d79b37c074f418c8d2e8f6600ba01a42021-11-18T07:03:24ZPlatelet serotonin level predicts survival in amyotrophic lateral sclerosis.1932-620310.1371/journal.pone.0013346https://doaj.org/article/6d79b37c074f418c8d2e8f6600ba01a42010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20967129/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease involving upper and lower motor neurons loss. Clinical features are highly variable among patients and there are currently few known disease-modifying factors underlying this heterogeneity. Serotonin is involved in a range of functions altered in ALS, including motor neuron excitability and energy metabolism. However, whether serotoninergic activity represents a disease modifier of ALS natural history remains unknown.<h4>Methodology</h4>Platelet and plasma unconjugated concentrations of serotonin and plasma 5-HIAA, the major serotonin metabolite, levels were measured using HPLC with coulometric detection in a cohort of 85 patients with ALS all followed-up until death and compared to a control group of 29 subjects.<h4>Principal findings</h4>Platelet serotonin levels were significantly decreased in ALS patients. Platelet serotonin levels did not correlate with disease duration but were positively correlated with survival of the patients. Univariate Cox model analysis showed a 57% decreased risk of death for patients with platelet serotonin levels in the normal range relative to patients with abnormally low platelet serotonin (p = 0.0195). This protective effect remained significant after adjustment with age, gender or site of onset in multivariate analysis. Plasma unconjugated serotonin and 5-HIAA levels were unchanged in ALS patients compared to controls and did not correlate with clinical parameters.<h4>Conclusions/significance</h4>The positive correlation between platelet serotonin levels and survival strongly suggests that serotonin influences the course of ALS disease.Luc DupuisOdile Spreux-VaroquauxGilbert BensimonPhilippe JullienLucette LacomblezFrançois SalachasGaëlle BruneteauPierre-François PradatJean-Philippe LoefflerVincent MeiningerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10, p e13346 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luc Dupuis Odile Spreux-Varoquaux Gilbert Bensimon Philippe Jullien Lucette Lacomblez François Salachas Gaëlle Bruneteau Pierre-François Pradat Jean-Philippe Loeffler Vincent Meininger Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.
description	<h4>Background</h4>Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease involving upper and lower motor neurons loss. Clinical features are highly variable among patients and there are currently few known disease-modifying factors underlying this heterogeneity. Serotonin is involved in a range of functions altered in ALS, including motor neuron excitability and energy metabolism. However, whether serotoninergic activity represents a disease modifier of ALS natural history remains unknown.<h4>Methodology</h4>Platelet and plasma unconjugated concentrations of serotonin and plasma 5-HIAA, the major serotonin metabolite, levels were measured using HPLC with coulometric detection in a cohort of 85 patients with ALS all followed-up until death and compared to a control group of 29 subjects.<h4>Principal findings</h4>Platelet serotonin levels were significantly decreased in ALS patients. Platelet serotonin levels did not correlate with disease duration but were positively correlated with survival of the patients. Univariate Cox model analysis showed a 57% decreased risk of death for patients with platelet serotonin levels in the normal range relative to patients with abnormally low platelet serotonin (p = 0.0195). This protective effect remained significant after adjustment with age, gender or site of onset in multivariate analysis. Plasma unconjugated serotonin and 5-HIAA levels were unchanged in ALS patients compared to controls and did not correlate with clinical parameters.<h4>Conclusions/significance</h4>The positive correlation between platelet serotonin levels and survival strongly suggests that serotonin influences the course of ALS disease.
format	article
author	Luc Dupuis Odile Spreux-Varoquaux Gilbert Bensimon Philippe Jullien Lucette Lacomblez François Salachas Gaëlle Bruneteau Pierre-François Pradat Jean-Philippe Loeffler Vincent Meininger
author_facet	Luc Dupuis Odile Spreux-Varoquaux Gilbert Bensimon Philippe Jullien Lucette Lacomblez François Salachas Gaëlle Bruneteau Pierre-François Pradat Jean-Philippe Loeffler Vincent Meininger
author_sort	Luc Dupuis
title	Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.
title_short	Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.
title_full	Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.
title_fullStr	Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.
title_full_unstemmed	Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.
title_sort	platelet serotonin level predicts survival in amyotrophic lateral sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/6d79b37c074f418c8d2e8f6600ba01a4
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Platelet serotonin level predicts survival in amyotrophic lateral sclerosis.

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