Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse

Cytotoxic T lymphocytes recognise and eliminate tumour cells. Here, the authors show that on contact with these immune cells melanoma cells can resist T cell cytotoxicity by modulating the trafficking of their lysosomal compartment, this results in the degradation of the T cell protein perforin by t...

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Autores principales:	Roxana Khazen, Sabina Müller, Nicolas Gaudenzio, Eric Espinosa, Marie-Pierre Puissegur, Salvatore Valitutti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6d7abd7b4f83446997c996c983b66c0d
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spelling	oai:doaj.org-article:6d7abd7b4f83446997c996c983b66c0d2021-12-02T15:33:48ZMelanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse10.1038/ncomms108232041-1723https://doaj.org/article/6d7abd7b4f83446997c996c983b66c0d2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10823https://doaj.org/toc/2041-1723Cytotoxic T lymphocytes recognise and eliminate tumour cells. Here, the authors show that on contact with these immune cells melanoma cells can resist T cell cytotoxicity by modulating the trafficking of their lysosomal compartment, this results in the degradation of the T cell protein perforin by the protease cathepsin B.Roxana KhazenSabina MüllerNicolas GaudenzioEric EspinosaMarie-Pierre PuissegurSalvatore ValituttiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roxana Khazen Sabina Müller Nicolas Gaudenzio Eric Espinosa Marie-Pierre Puissegur Salvatore Valitutti Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse
description	Cytotoxic T lymphocytes recognise and eliminate tumour cells. Here, the authors show that on contact with these immune cells melanoma cells can resist T cell cytotoxicity by modulating the trafficking of their lysosomal compartment, this results in the degradation of the T cell protein perforin by the protease cathepsin B.
format	article
author	Roxana Khazen Sabina Müller Nicolas Gaudenzio Eric Espinosa Marie-Pierre Puissegur Salvatore Valitutti
author_facet	Roxana Khazen Sabina Müller Nicolas Gaudenzio Eric Espinosa Marie-Pierre Puissegur Salvatore Valitutti
author_sort	Roxana Khazen
title	Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse
title_short	Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse
title_full	Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse
title_fullStr	Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse
title_full_unstemmed	Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse
title_sort	melanoma cell lysosome secretory burst neutralizes the ctl-mediated cytotoxicity at the lytic synapse
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6d7abd7b4f83446997c996c983b66c0d
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Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse

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