In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating

Yonggang Dang,1 Li Zhang,1 Wen Song,1 Bei Chang,1 Tianxiao Han,1 Yumei Zhang,1 Lingzhou Zhao2 1Department of Prosthetic Dentistry, 2Department of Periodontology, School of Stomatology, State Key Laboratory of Military Stomatology, The Fourth Military Medical University, Xi’an, People&...

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Autores principales:	Dang Y, Zhang L, Song W, Chang B, Han T, Zhang Y, Zhao L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Titania nanotubes Strontium Osseointegration In vivo Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6d7b5ccc98a9478a990d3fe4849af56c
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spelling	oai:doaj.org-article:6d7b5ccc98a9478a990d3fe4849af56c2021-12-02T01:34:50ZIn vivo osseointegration of Ti implants with a strontium-containing nanotubular coating1178-2013https://doaj.org/article/6d7b5ccc98a9478a990d3fe4849af56c2016-03-01T00:00:00Zhttps://www.dovepress.com/in-vivo-osseointegration-of-ti-implants-with-a-strontium-containing-na-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yonggang Dang,1 Li Zhang,1 Wen Song,1 Bei Chang,1 Tianxiao Han,1 Yumei Zhang,1 Lingzhou Zhao2 1Department of Prosthetic Dentistry, 2Department of Periodontology, School of Stomatology, State Key Laboratory of Military Stomatology, The Fourth Military Medical University, Xi’an, People’s Republic of China Abstract: Novel biomedical titanium (Ti) implants with high osteogenic ability for fast and good osseointegration under normal as well as osteoporotic conditions are urgently needed. Expanding on our previous in vitro results, we hypothesized that nanotubular, strontium-loaded (NT-Sr) structures on Ti implants would have favorable osteogenic effects and evaluated the in vivo osseointegration of these implants in rats. The structures with nanotubes of different diameters were fabricated by electrochemical anodization at 10 and 40 V, and the amounts of Sr loaded were adjusted by using two hydrothermal treatment times of 1 and 3 hours. Qualitative microcomputed tomography in two and three dimensions showed that the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours best supported bone growth in vivo. Histomorphometric examination of osseointegration also showed that more newly formed bone was found at its surface. The bone–implant contact percentage was highest (92.48%±0.76%) at 12 weeks. In conclusion, the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours showed excellent osteogenic properties, making it an attractive option for Ti surface modification with considerable clinical potential. Keywords: titania nanotubes, strontium, osseointegration, in vivoDang YZhang LSong WChang BHan TZhang YZhao LDove Medical PressarticleTitania nanotubesStrontiumOsseointegrationIn vivoMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1003-1011 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Titania nanotubes Strontium Osseointegration In vivo Medicine (General) R5-920
spellingShingle	Titania nanotubes Strontium Osseointegration In vivo Medicine (General) R5-920 Dang Y Zhang L Song W Chang B Han T Zhang Y Zhao L In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating
description	Yonggang Dang,1 Li Zhang,1 Wen Song,1 Bei Chang,1 Tianxiao Han,1 Yumei Zhang,1 Lingzhou Zhao2 1Department of Prosthetic Dentistry, 2Department of Periodontology, School of Stomatology, State Key Laboratory of Military Stomatology, The Fourth Military Medical University, Xi’an, People’s Republic of China Abstract: Novel biomedical titanium (Ti) implants with high osteogenic ability for fast and good osseointegration under normal as well as osteoporotic conditions are urgently needed. Expanding on our previous in vitro results, we hypothesized that nanotubular, strontium-loaded (NT-Sr) structures on Ti implants would have favorable osteogenic effects and evaluated the in vivo osseointegration of these implants in rats. The structures with nanotubes of different diameters were fabricated by electrochemical anodization at 10 and 40 V, and the amounts of Sr loaded were adjusted by using two hydrothermal treatment times of 1 and 3 hours. Qualitative microcomputed tomography in two and three dimensions showed that the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours best supported bone growth in vivo. Histomorphometric examination of osseointegration also showed that more newly formed bone was found at its surface. The bone–implant contact percentage was highest (92.48%±0.76%) at 12 weeks. In conclusion, the NT-Sr formed with an anodization voltage of 10 V and hydrothermal treatment time of 3 hours showed excellent osteogenic properties, making it an attractive option for Ti surface modification with considerable clinical potential. Keywords: titania nanotubes, strontium, osseointegration, in vivo
format	article
author	Dang Y Zhang L Song W Chang B Han T Zhang Y Zhao L
author_facet	Dang Y Zhang L Song W Chang B Han T Zhang Y Zhao L
author_sort	Dang Y
title	In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating
title_short	In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating
title_full	In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating
title_fullStr	In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating
title_full_unstemmed	In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating
title_sort	in vivo osseointegration of ti implants with a strontium-containing nanotubular coating
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/6d7b5ccc98a9478a990d3fe4849af56c
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In vivo osseointegration of Ti implants with a strontium-containing nanotubular coating

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