THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS

Evolution of existing paradigms on regenerative capacity of the central nervous system (CNS) and eventual role of immune cells in restoration of damaged nervous tissue offers new prospectives in treatment of neurological disorders based on immunotherapeutic approaches. Present review article address...

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Autores principales:	E. R. Chernykh, E. Ya. Shevela, A. A. Ostanin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	central nervous system macrophages microglia monocyte-derived macrophages functional phenotypes neuroprotection neuroregeneration angiogenesis cerebral palsy stroke regenerative immunotherapy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6d7c42c9e9874fb381016eeff0d533a9
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spelling	oai:doaj.org-article:6d7c42c9e9874fb381016eeff0d533a92021-11-18T08:03:45ZTHE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS1563-06252313-741X10.15789/1563-0625-2017-1-7-18https://doaj.org/article/6d7c42c9e9874fb381016eeff0d533a92017-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1158https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XEvolution of existing paradigms on regenerative capacity of the central nervous system (CNS) and eventual role of immune cells in restoration of damaged nervous tissue offers new prospectives in treatment of neurological disorders based on immunotherapeutic approaches. Present review article addresses a role of macrophages in restoration of damaged CNS and provides data on functional heterogeneity of resident tissue macrophages (microglia), and monocyte-derived macrophages. We discuss possible ways of monocyte recruitment to CNS, relationships between microglia and recruited macrophages, as well as M1/M2 balance in neurological conditions. Moreover, the review proposes an experimental rationale for macrophage engagement into the CNS damage reconstruction, and concerns the mechanisms of macrophage regenerative activity. In summary, the data presented here allow us to suggest macrophages as a novel therapeutic target for suppression of neuroinflammation and enhancement of reparative processes. The first steps in the field are encouraging, with respect to clinical application of monocytes/macrophages or M1→M2 switching technologies for treatment of the neurological disorders, thus presuming a need for further research in this direction.E. R. ChernykhE. Ya. ShevelaA. A. OstaninSPb RAACIarticlecentral nervous systemmacrophagesmicrogliamonocyte-derived macrophagesfunctional phenotypesneuroprotectionneuroregenerationangiogenesiscerebral palsystrokeregenerative immunotherapyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 1, Pp 7-18 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	central nervous system macrophages microglia monocyte-derived macrophages functional phenotypes neuroprotection neuroregeneration angiogenesis cerebral palsy stroke regenerative immunotherapy Immunologic diseases. Allergy RC581-607
spellingShingle	central nervous system macrophages microglia monocyte-derived macrophages functional phenotypes neuroprotection neuroregeneration angiogenesis cerebral palsy stroke regenerative immunotherapy Immunologic diseases. Allergy RC581-607 E. R. Chernykh E. Ya. Shevela A. A. Ostanin THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
description	Evolution of existing paradigms on regenerative capacity of the central nervous system (CNS) and eventual role of immune cells in restoration of damaged nervous tissue offers new prospectives in treatment of neurological disorders based on immunotherapeutic approaches. Present review article addresses a role of macrophages in restoration of damaged CNS and provides data on functional heterogeneity of resident tissue macrophages (microglia), and monocyte-derived macrophages. We discuss possible ways of monocyte recruitment to CNS, relationships between microglia and recruited macrophages, as well as M1/M2 balance in neurological conditions. Moreover, the review proposes an experimental rationale for macrophage engagement into the CNS damage reconstruction, and concerns the mechanisms of macrophage regenerative activity. In summary, the data presented here allow us to suggest macrophages as a novel therapeutic target for suppression of neuroinflammation and enhancement of reparative processes. The first steps in the field are encouraging, with respect to clinical application of monocytes/macrophages or M1→M2 switching technologies for treatment of the neurological disorders, thus presuming a need for further research in this direction.
format	article
author	E. R. Chernykh E. Ya. Shevela A. A. Ostanin
author_facet	E. R. Chernykh E. Ya. Shevela A. A. Ostanin
author_sort	E. R. Chernykh
title	THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
title_short	THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
title_full	THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
title_fullStr	THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
title_full_unstemmed	THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
title_sort	role of macrophages in damage recovery of central nervous system: new options for treatment of neurological disorders
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/6d7c42c9e9874fb381016eeff0d533a9
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THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS

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