Paradoxical SAPHO syndrome observed during anti-TNF-α therapy for Crohn's disease
Hitoshi Amano,1 Reikei Matsuda,1 Tomohiko Shibata,2 Daisuke Takahashi,1 Shinichiro Suzuki3 1Department of Gastroenterology, Fujisawa Shonandai Hospital, Fujisawa, 2Division of Rheumatology, Department of Internal Medicine, St Marianna University School of Medicine, Yokohama City Seibu Hospital, Yoko...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/6d7ce30949364659b6121d8a0ea7d447 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:6d7ce30949364659b6121d8a0ea7d447 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:6d7ce30949364659b6121d8a0ea7d4472021-12-02T03:57:26ZParadoxical SAPHO syndrome observed during anti-TNF-α therapy for Crohn's disease1177-5491https://doaj.org/article/6d7ce30949364659b6121d8a0ea7d4472017-05-01T00:00:00Zhttps://www.dovepress.com/paradoxical-sapho-syndrome-observed-during-anti-tnf-alpha-therapy-for--peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Hitoshi Amano,1 Reikei Matsuda,1 Tomohiko Shibata,2 Daisuke Takahashi,1 Shinichiro Suzuki3 1Department of Gastroenterology, Fujisawa Shonandai Hospital, Fujisawa, 2Division of Rheumatology, Department of Internal Medicine, St Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, 3Department of Surgery, Fujisawa Shonandai Hospital, Fujisawa, Japan Abstract: Currently, anti-TNFα antibodies are used to treat Crohn’s disease. We report on a 45-year-old Japanese female with Crohn’s disease developing SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome following exposure to the anti-TNFα antibody adalimumab. Initially, adalimumab induced remission, but the patient showed SAPHO syndrome 11 weeks following the start of adalimumab therapy for the first time. Cutaneous and articular involvement were exacerbating the condition, so adalimumab was discontinued and the patient was put on low-dose methotrexate to control her symptoms. To our knowledge, this is the first report of SAPHO syndrome occurring during anti-TNF therapy, which is thought to be a paradoxical response to adalimumab. Keywords: anti-TNFα, adalimumab, paradoxical reaction, SAPHO syndrome, Crohn’s diseaseAmano HMatsuda RShibata TTakahashi DSuzuki SDove Medical PressarticleSAPHO syndromeparadoxical reactionCrohn diseaseanti-TNF-α therapyadalimumabMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 11, Pp 65-69 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
SAPHO syndrome paradoxical reaction Crohn disease anti-TNF-α therapy adalimumab Medicine (General) R5-920 |
| spellingShingle |
SAPHO syndrome paradoxical reaction Crohn disease anti-TNF-α therapy adalimumab Medicine (General) R5-920 Amano H Matsuda R Shibata T Takahashi D Suzuki S Paradoxical SAPHO syndrome observed during anti-TNF-α therapy for Crohn's disease |
| description |
Hitoshi Amano,1 Reikei Matsuda,1 Tomohiko Shibata,2 Daisuke Takahashi,1 Shinichiro Suzuki3 1Department of Gastroenterology, Fujisawa Shonandai Hospital, Fujisawa, 2Division of Rheumatology, Department of Internal Medicine, St Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, 3Department of Surgery, Fujisawa Shonandai Hospital, Fujisawa, Japan Abstract: Currently, anti-TNFα antibodies are used to treat Crohn’s disease. We report on a 45-year-old Japanese female with Crohn’s disease developing SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome following exposure to the anti-TNFα antibody adalimumab. Initially, adalimumab induced remission, but the patient showed SAPHO syndrome 11 weeks following the start of adalimumab therapy for the first time. Cutaneous and articular involvement were exacerbating the condition, so adalimumab was discontinued and the patient was put on low-dose methotrexate to control her symptoms. To our knowledge, this is the first report of SAPHO syndrome occurring during anti-TNF therapy, which is thought to be a paradoxical response to adalimumab. Keywords: anti-TNFα, adalimumab, paradoxical reaction, SAPHO syndrome, Crohn’s disease |
| format |
article |
| author |
Amano H Matsuda R Shibata T Takahashi D Suzuki S |
| author_facet |
Amano H Matsuda R Shibata T Takahashi D Suzuki S |
| author_sort |
Amano H |
| title |
Paradoxical SAPHO syndrome observed during anti-TNF-α therapy for Crohn's disease |
| title_short |
Paradoxical SAPHO syndrome observed during anti-TNF-α therapy for Crohn's disease |
| title_full |
Paradoxical SAPHO syndrome observed during anti-TNF-α therapy for Crohn's disease |
| title_fullStr |
Paradoxical SAPHO syndrome observed during anti-TNF-α therapy for Crohn's disease |
| title_full_unstemmed |
Paradoxical SAPHO syndrome observed during anti-TNF-α therapy for Crohn's disease |
| title_sort |
paradoxical sapho syndrome observed during anti-tnf-α therapy for crohn's disease |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/6d7ce30949364659b6121d8a0ea7d447 |
| work_keys_str_mv |
AT amanoh paradoxicalsaphosyndromeobservedduringantitnfalphatherapyforcrohn39sdisease AT matsudar paradoxicalsaphosyndromeobservedduringantitnfalphatherapyforcrohn39sdisease AT shibatat paradoxicalsaphosyndromeobservedduringantitnfalphatherapyforcrohn39sdisease AT takahashid paradoxicalsaphosyndromeobservedduringantitnfalphatherapyforcrohn39sdisease AT suzukis paradoxicalsaphosyndromeobservedduringantitnfalphatherapyforcrohn39sdisease |
| _version_ |
1718401555852427264 |