Bone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF): Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD)

Bone morphogenetic proteins (BMP), extracellular matrix metalloproteinases inducer (EMMPRIN), and macrophage migration inhibitory factor (MIF) are known to be closely connected to renal tubule damage by experimental data; however, this has not been analyzed in children with chronic kidney disease (C...

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Autores principales:	Kinga Musiał, Danuta Zwolińska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bone morphogenetic protein (BMP)-2 bone morphogenetic protein (BMP)-6 extracellular matrix metalloproteinases inducer (EMMPRIN) macrophage migration inhibitory factor (MIF) tubular functional reserve tubular damage Medicine R
Acceso en línea:	https://doaj.org/article/6d7ee66e720246d985a2b74d6184b33f
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spelling	oai:doaj.org-article:6d7ee66e720246d985a2b74d6184b33f2021-11-11T17:32:40ZBone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF): Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD)10.3390/jcm102148932077-0383https://doaj.org/article/6d7ee66e720246d985a2b74d6184b33f2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4893https://doaj.org/toc/2077-0383Bone morphogenetic proteins (BMP), extracellular matrix metalloproteinases inducer (EMMPRIN), and macrophage migration inhibitory factor (MIF) are known to be closely connected to renal tubule damage by experimental data; however, this has not been analyzed in children with chronic kidney disease (CKD). The aim of this study was to determine their usefulness in the assessment of CKD-related tubular dysfunction. The study group consisted of 61 children with CKD stages 1–5 and 23 controls. The serum and urine concentrations of BMP-2, BMP-6, EMMPRIN, and MIF were assessed by ELISA and their fractional excretion (FE) was calculated. The serum and urine concentrations of BMP-2, BMP-6, EMMPRIN, and MIF were significantly elevated in children with CKD vs. controls. The FE of BMP-2, FE BMP-6, and EMMPRIN increased significantly in CKD stages 1–2, but exceeded 1% in CKD stages 3–5. FE MIF became higher than in controls no sooner than in CKD 3–5, but remained below 1%. The FE values for BMP-2, BMP-6, and EMMPRIN of <1% may result from the tubular adaptive mechanisms, whereas those surpassing 1% suggest irreversible tubular damage. The analysis of serum/urinary concentrations and fractional excretion of examined parameters may allow the assessment of CKD-related tubular dysfunction.Kinga MusiałDanuta ZwolińskaMDPI AGarticlebone morphogenetic protein (BMP)-2bone morphogenetic protein (BMP)-6extracellular matrix metalloproteinases inducer (EMMPRIN)macrophage migration inhibitory factor (MIF)tubular functional reservetubular damageMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4893, p 4893 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone morphogenetic protein (BMP)-2 bone morphogenetic protein (BMP)-6 extracellular matrix metalloproteinases inducer (EMMPRIN) macrophage migration inhibitory factor (MIF) tubular functional reserve tubular damage Medicine R
spellingShingle	bone morphogenetic protein (BMP)-2 bone morphogenetic protein (BMP)-6 extracellular matrix metalloproteinases inducer (EMMPRIN) macrophage migration inhibitory factor (MIF) tubular functional reserve tubular damage Medicine R Kinga Musiał Danuta Zwolińska Bone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF): Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD)
description	Bone morphogenetic proteins (BMP), extracellular matrix metalloproteinases inducer (EMMPRIN), and macrophage migration inhibitory factor (MIF) are known to be closely connected to renal tubule damage by experimental data; however, this has not been analyzed in children with chronic kidney disease (CKD). The aim of this study was to determine their usefulness in the assessment of CKD-related tubular dysfunction. The study group consisted of 61 children with CKD stages 1–5 and 23 controls. The serum and urine concentrations of BMP-2, BMP-6, EMMPRIN, and MIF were assessed by ELISA and their fractional excretion (FE) was calculated. The serum and urine concentrations of BMP-2, BMP-6, EMMPRIN, and MIF were significantly elevated in children with CKD vs. controls. The FE of BMP-2, FE BMP-6, and EMMPRIN increased significantly in CKD stages 1–2, but exceeded 1% in CKD stages 3–5. FE MIF became higher than in controls no sooner than in CKD 3–5, but remained below 1%. The FE values for BMP-2, BMP-6, and EMMPRIN of <1% may result from the tubular adaptive mechanisms, whereas those surpassing 1% suggest irreversible tubular damage. The analysis of serum/urinary concentrations and fractional excretion of examined parameters may allow the assessment of CKD-related tubular dysfunction.
format	article
author	Kinga Musiał Danuta Zwolińska
author_facet	Kinga Musiał Danuta Zwolińska
author_sort	Kinga Musiał
title	Bone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF): Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD)
title_short	Bone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF): Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD)
title_full	Bone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF): Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD)
title_fullStr	Bone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF): Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD)
title_full_unstemmed	Bone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF): Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD)
title_sort	bone morphogenetic proteins (bmps), extracellular matrix metalloproteinases inducer (emmprin), and macrophage migration inhibitory factor (mif): usefulness in the assessment of tubular dysfunction related to chronic kidney disease (ckd)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6d7ee66e720246d985a2b74d6184b33f
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_version_	1718432068078141440

Bone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF): Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD)

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