PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.

PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.

Porcupine (PORCN) is a membrane-bound O-acyl transferase that is required for the palmitoylation of Wnt proteins, and that is essential in diverse Wnt pathways for Wnt-Wntless (WLS) binding, Wnt secretion, and Wnt signaling activity. We tested if PORCN was required for the proliferation of transform...

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Autores principales: Tracy M Covey, Simran Kaur, Tina Tan Ong, Kyle D Proffitt, Yonghui Wu, Patrick Tan, David M Virshup
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6d803ceca73949ce8406e72b0add2d83
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