No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.

Brain-derived neurotrophic factor (BDNF) has been suggested to play a major role in plasticity, neurogenesis and learning in the adult brain. The BDNF gene contains a common val66met polymorphism associated with decreased activity-dependent excretion of BDNF and a potential influence on behaviour, m...

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Autores principales:	Nils Freundlieb, Stephan Philipp, Susanne A Schneider, Norbert Brüggemann, Christine Klein, Christian Gerloff, Friedhelm C Hummel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d822b51b1334ed0a42152ed0483c4f8
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spelling	oai:doaj.org-article:6d822b51b1334ed0a42152ed0483c4f82021-11-18T08:09:02ZNo association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.1932-620310.1371/journal.pone.0048327https://doaj.org/article/6d822b51b1334ed0a42152ed0483c4f82012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23152767/?tool=EBIhttps://doaj.org/toc/1932-6203Brain-derived neurotrophic factor (BDNF) has been suggested to play a major role in plasticity, neurogenesis and learning in the adult brain. The BDNF gene contains a common val66met polymorphism associated with decreased activity-dependent excretion of BDNF and a potential influence on behaviour, more specifically, on motor learning. The objective of this study was to determine the influence of the BDNF val66met polymorphism on short-term implicit associative learning and whether its influence is cognitive domain-specific (motor vs. language). A sample of 38 young healthy participants was genotyped, screened for background and neuropsychological differences, and tested with two associative implicit learning paradigms in two different cognitive domains, i.e., motor and vocabulary learning. Subjects performed the serial reaction time task (SRTT) to determine implicit motor learning and a recently established associative vocabulary learning task (AVL) for implicit learning of action and object words. To determine the influence of the BDNF polymorphism on domain-specific implicit learning, behavioural improvements in the two tasks were compared between val/val (n = 22) and met carriers (val/met: n = 15 and met/met: n = 1). There was no evidence for an impact of the BDNF val66met polymorphism on the behavioural outcome in implicit short-term learning paradigms in young healthy subjects. Whether this polymorphism plays a relevant role in long-term training paradigms or in subjects with impaired neuronal plasticity or reduced learning capacity, such as aged individuals, demented patients or patients with brain lesions, has to be determined in future studies.Nils FreundliebStephan PhilippSusanne A SchneiderNorbert BrüggemannChristine KleinChristian GerloffFriedhelm C HummelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48327 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nils Freundlieb Stephan Philipp Susanne A Schneider Norbert Brüggemann Christine Klein Christian Gerloff Friedhelm C Hummel No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.
description	Brain-derived neurotrophic factor (BDNF) has been suggested to play a major role in plasticity, neurogenesis and learning in the adult brain. The BDNF gene contains a common val66met polymorphism associated with decreased activity-dependent excretion of BDNF and a potential influence on behaviour, more specifically, on motor learning. The objective of this study was to determine the influence of the BDNF val66met polymorphism on short-term implicit associative learning and whether its influence is cognitive domain-specific (motor vs. language). A sample of 38 young healthy participants was genotyped, screened for background and neuropsychological differences, and tested with two associative implicit learning paradigms in two different cognitive domains, i.e., motor and vocabulary learning. Subjects performed the serial reaction time task (SRTT) to determine implicit motor learning and a recently established associative vocabulary learning task (AVL) for implicit learning of action and object words. To determine the influence of the BDNF polymorphism on domain-specific implicit learning, behavioural improvements in the two tasks were compared between val/val (n = 22) and met carriers (val/met: n = 15 and met/met: n = 1). There was no evidence for an impact of the BDNF val66met polymorphism on the behavioural outcome in implicit short-term learning paradigms in young healthy subjects. Whether this polymorphism plays a relevant role in long-term training paradigms or in subjects with impaired neuronal plasticity or reduced learning capacity, such as aged individuals, demented patients or patients with brain lesions, has to be determined in future studies.
format	article
author	Nils Freundlieb Stephan Philipp Susanne A Schneider Norbert Brüggemann Christine Klein Christian Gerloff Friedhelm C Hummel
author_facet	Nils Freundlieb Stephan Philipp Susanne A Schneider Norbert Brüggemann Christine Klein Christian Gerloff Friedhelm C Hummel
author_sort	Nils Freundlieb
title	No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.
title_short	No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.
title_full	No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.
title_fullStr	No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.
title_full_unstemmed	No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.
title_sort	no association of the bdnf val66met polymorphism with implicit associative vocabulary and motor learning.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6d822b51b1334ed0a42152ed0483c4f8
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No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.

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