Recent insights into the biological activities and drug delivery systems of tanshinones

Yuee Cai,1,* Wenji Zhang,2,* Zirong Chen,3 Zhi Shi,1,2 Chengwei He,1 Meiwan Chen1 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China; 2Department of Cell Biology & Institute o...

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Autores principales:	Cai Y, Zhang W, Chen Z, Shi Z, He C, Chen M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	tanshinones biological activities drug delivery systems. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6d85084c0efe4445bf80cd083986c030
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spelling	oai:doaj.org-article:6d85084c0efe4445bf80cd083986c0302021-12-02T01:32:31ZRecent insights into the biological activities and drug delivery systems of tanshinones1178-2013https://doaj.org/article/6d85084c0efe4445bf80cd083986c0302016-01-01T00:00:00Zhttps://www.dovepress.com/recent-insights-into-the-biological-activities-andnbspdrug-delivery-sy-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yuee Cai,1,* Wenji Zhang,2,* Zirong Chen,3 Zhi Shi,1,2 Chengwei He,1 Meiwan Chen1 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China; 2Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, People’s Republic of China; 3Department of Molecular Genetics and Microbiology, Shands Cancer Center, University of Florida, Gainesville, FL, USA *These authors contributed equally to this work Abstract: Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal herb Tanshen (Salvia miltiorrhiza), have attracted growing scientific attention because of the prospective biomedical applications of these compounds. Numerous pharmacological activities, including anti-inflammatory, anticancer, and cardio-cerebrovascular protection activities, are exhibited by the three primary bioactive constituents among the tanshinones, ie, tanshinone I (TNI), tanshinone IIA (TNIIA), and cryptotanshinone (CPT). However, due to their poor solubility and low dissolution rate, the clinical applications of TNI, TNIIA, and CPT are limited. To solve these problems, many studies have focused on loading tanshinones into liposomes, nanoparticles, microemulsions, cyclodextrin inclusions, solid dispersions, and so on. In this review, we aim to offer an updated summary of the biological activities and drug delivery systems of tanshinones to provide a reference for these constituents in clinical applications. Keywords: tanshinones, biological activities, drug delivery systems, bioavailability, solubilityCai YZhang WChen ZShi ZHe CChen MDove Medical Pressarticletanshinonesbiological activitiesdrug delivery systems.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss Issue 1, Pp 121-130 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	tanshinones biological activities drug delivery systems. Medicine (General) R5-920
spellingShingle	tanshinones biological activities drug delivery systems. Medicine (General) R5-920 Cai Y Zhang W Chen Z Shi Z He C Chen M Recent insights into the biological activities and drug delivery systems of tanshinones
description	Yuee Cai,1,* Wenji Zhang,2,* Zirong Chen,3 Zhi Shi,1,2 Chengwei He,1 Meiwan Chen1 1State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China; 2Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, People’s Republic of China; 3Department of Molecular Genetics and Microbiology, Shands Cancer Center, University of Florida, Gainesville, FL, USA *These authors contributed equally to this work Abstract: Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal herb Tanshen (Salvia miltiorrhiza), have attracted growing scientific attention because of the prospective biomedical applications of these compounds. Numerous pharmacological activities, including anti-inflammatory, anticancer, and cardio-cerebrovascular protection activities, are exhibited by the three primary bioactive constituents among the tanshinones, ie, tanshinone I (TNI), tanshinone IIA (TNIIA), and cryptotanshinone (CPT). However, due to their poor solubility and low dissolution rate, the clinical applications of TNI, TNIIA, and CPT are limited. To solve these problems, many studies have focused on loading tanshinones into liposomes, nanoparticles, microemulsions, cyclodextrin inclusions, solid dispersions, and so on. In this review, we aim to offer an updated summary of the biological activities and drug delivery systems of tanshinones to provide a reference for these constituents in clinical applications. Keywords: tanshinones, biological activities, drug delivery systems, bioavailability, solubility
format	article
author	Cai Y Zhang W Chen Z Shi Z He C Chen M
author_facet	Cai Y Zhang W Chen Z Shi Z He C Chen M
author_sort	Cai Y
title	Recent insights into the biological activities and drug delivery systems of tanshinones
title_short	Recent insights into the biological activities and drug delivery systems of tanshinones
title_full	Recent insights into the biological activities and drug delivery systems of tanshinones
title_fullStr	Recent insights into the biological activities and drug delivery systems of tanshinones
title_full_unstemmed	Recent insights into the biological activities and drug delivery systems of tanshinones
title_sort	recent insights into the biological activities and drug delivery systems of tanshinones
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/6d85084c0efe4445bf80cd083986c030
work_keys_str_mv	AT caiy recentinsightsintothebiologicalactivitiesandnbspdrugdeliverysystemsoftanshinones AT zhangw recentinsightsintothebiologicalactivitiesandnbspdrugdeliverysystemsoftanshinones AT chenz recentinsightsintothebiologicalactivitiesandnbspdrugdeliverysystemsoftanshinones AT shiz recentinsightsintothebiologicalactivitiesandnbspdrugdeliverysystemsoftanshinones AT hec recentinsightsintothebiologicalactivitiesandnbspdrugdeliverysystemsoftanshinones AT chenm recentinsightsintothebiologicalactivitiesandnbspdrugdeliverysystemsoftanshinones
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Recent insights into the biological activities and&nbsp;drug delivery systems of tanshinones

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Recent insights into the biological activities and drug delivery systems of tanshinones