Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

Camila Zanella Benfica,1,2 Teresinha Zanella,3 Lucas Brandolt Farias,1,2 Maria Lúcia Rocha Oppermann,1,3 Luis Henrique Santos Canani,1,4 Daniel Lavinsky1,2 1Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; 2Department of Ophthalmology, Hospital de Clíni...

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Autores principales:	Benfica CZ, Zanella T, Farias LB, Oppermann MLR, Canani LH, Lavinsky D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Choroid Enhanced depth imaging optical coherence tomography Pregnancy Gestational Diabetes Mellitus Diabetes Mellitus. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6d851da3e73048dabd306d9e1e0e6737
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spelling	oai:doaj.org-article:6d851da3e73048dabd306d9e1e0e67372021-12-02T07:43:55ZMacular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography1177-5483https://doaj.org/article/6d851da3e73048dabd306d9e1e0e67372018-07-01T00:00:00Zhttps://www.dovepress.com/macular-choroidal-thickness-in-pregnant-women-with-type-1-type-2-and-g-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Camila Zanella Benfica,1,2 Teresinha Zanella,3 Lucas Brandolt Farias,1,2 Maria Lúcia Rocha Oppermann,1,3 Luis Henrique Santos Canani,1,4 Daniel Lavinsky1,2 1Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; 2Department of Ophthalmology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; 3Department of Gynecology and Obstetrics, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; 4Department of Endocrinology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Purpose: To analyze choroidal thickness (CT) of pregnant women with type 1 diabetes mellitus (DM), type 2 DM and gestational diabetes mellitus (GDM) using spectral-domain optical coherence tomography. Patients and methods: This cross-sectional study included 144 eyes of 72 pregnant women in the third trimester divided into four groups: 27 non-diabetic pregnant women; 15 pregnant women with GDM; 16 with type 2 DM and 14 with type 1 DM. CT was measured using optical coherence tomography at ten different locations. We also analyzed possible confounding factors, such as gestational age, glycosylated hemoglobin, time from DM diagnosis, hypertension and severity of diabetic retinopathy. Results: The comparison between the four groups showed a thinner choroid in patients with type 1 DM in all locations, with statistical significance in subfoveal and temporal measurements. When comparing only patients with type 1 and type 2 DM, adjusting for confounding factors, the choroid of patients with type 1 DM remained thinner at all macular points, also with statistical significance in subfoveal and temporal measurements. Conclusion: Pregnant women with type 1 DM had significantly thinner CT measurements on subfoveal and temporal locations. No differences were found in CT between the control group and pregnant women with GDM and type 2 DM. Keywords: choroid, enhanced depth imaging optical coherence tomography, pregnancy, gestational diabetes mellitus, diabetes mellitusBenfica CZZanella TFarias LBOppermann MLRCanani LHLavinsky DDove Medical PressarticleChoroidEnhanced depth imaging optical coherence tomographyPregnancyGestational Diabetes MellitusDiabetes Mellitus.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1259-1265 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Choroid Enhanced depth imaging optical coherence tomography Pregnancy Gestational Diabetes Mellitus Diabetes Mellitus. Ophthalmology RE1-994
spellingShingle	Choroid Enhanced depth imaging optical coherence tomography Pregnancy Gestational Diabetes Mellitus Diabetes Mellitus. Ophthalmology RE1-994 Benfica CZ Zanella T Farias LB Oppermann MLR Canani LH Lavinsky D Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography
description	Camila Zanella Benfica,1,2 Teresinha Zanella,3 Lucas Brandolt Farias,1,2 Maria Lúcia Rocha Oppermann,1,3 Luis Henrique Santos Canani,1,4 Daniel Lavinsky1,2 1Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; 2Department of Ophthalmology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; 3Department of Gynecology and Obstetrics, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; 4Department of Endocrinology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Purpose: To analyze choroidal thickness (CT) of pregnant women with type 1 diabetes mellitus (DM), type 2 DM and gestational diabetes mellitus (GDM) using spectral-domain optical coherence tomography. Patients and methods: This cross-sectional study included 144 eyes of 72 pregnant women in the third trimester divided into four groups: 27 non-diabetic pregnant women; 15 pregnant women with GDM; 16 with type 2 DM and 14 with type 1 DM. CT was measured using optical coherence tomography at ten different locations. We also analyzed possible confounding factors, such as gestational age, glycosylated hemoglobin, time from DM diagnosis, hypertension and severity of diabetic retinopathy. Results: The comparison between the four groups showed a thinner choroid in patients with type 1 DM in all locations, with statistical significance in subfoveal and temporal measurements. When comparing only patients with type 1 and type 2 DM, adjusting for confounding factors, the choroid of patients with type 1 DM remained thinner at all macular points, also with statistical significance in subfoveal and temporal measurements. Conclusion: Pregnant women with type 1 DM had significantly thinner CT measurements on subfoveal and temporal locations. No differences were found in CT between the control group and pregnant women with GDM and type 2 DM. Keywords: choroid, enhanced depth imaging optical coherence tomography, pregnancy, gestational diabetes mellitus, diabetes mellitus
format	article
author	Benfica CZ Zanella T Farias LB Oppermann MLR Canani LH Lavinsky D
author_facet	Benfica CZ Zanella T Farias LB Oppermann MLR Canani LH Lavinsky D
author_sort	Benfica CZ
title	Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography
title_short	Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography
title_full	Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography
title_fullStr	Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography
title_full_unstemmed	Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography
title_sort	macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/6d851da3e73048dabd306d9e1e0e6737
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Macular choroidal thickness in pregnant women with type 1, type 2 and gestational diabetes mellitus measured by spectral-domain optical coherence tomography

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