COPD patients hospitalized with exacerbations have greater cognitive impairment than patients hospitalized with decompensated heart failure

Mohani-Preet K Bajaj,1 Daniel R Burrage,2 Andrew Tappouni,3 James W Dodd,4 Paul W Jones,2 Emma H Baker2 1Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George’s University of London, London, UK; 2Clinical Pharmacology, Institute of Infection and Immu...

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Autores principales:	Bajaj MPK, Burrage DR, Tappouni A, Dodd JW, Jones PW, Baker EH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Montreal Cognitive Assessment Cognition Comorbidities Systemic Smoking Hyperglycemia Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/6d874a13b9774062bb23263dce6c27fd
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spelling	oai:doaj.org-article:6d874a13b9774062bb23263dce6c27fd2021-12-02T01:12:55ZCOPD patients hospitalized with exacerbations have greater cognitive impairment than patients hospitalized with decompensated heart failure1178-1998https://doaj.org/article/6d874a13b9774062bb23263dce6c27fd2018-12-01T00:00:00Zhttps://www.dovepress.com/copd-patients-hospitalized-with-exacerbations-have-greater-cognitive-i-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Mohani-Preet K Bajaj,1 Daniel R Burrage,2 Andrew Tappouni,3 James W Dodd,4 Paul W Jones,2 Emma H Baker2 1Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George’s University of London, London, UK; 2Clinical Pharmacology, Institute of Infection and Immunity, St George’s University of London, London, UK; 3St George’s University of London, London, UK; 4Academic Respiratory Unit, University of Bristol, Bristol, UK Purpose: People with COPD have cognitive dysfunction, which is greater in those hospitalized for exacerbations than in stable outpatients. We tested the hypothesis that cognitive dysfunction at exacerbation is a disease-specific feature of COPD, rather than a nonspecific feature of hospitalization for acute illness, by comparing cognition between patients hospitalized for acute COPD exacerbations and those with worsening heart failure (HF). Patients and methods: A total of 40 hospital inpatients were recruited, 20 patients with COPD exacerbations and 20 patients with congestive or left-sided HF. Exclusion criteria included previous stroke, known neurological disease, and marked alcohol excess. Participants completed the Montreal cognitive assessment (MoCA) and Hospital Anxiety and Depression Scale (HADS) and underwent spirometry and review of clinical records. Results: Age (mean±SD, COPD 73±10; HF 76±11 years), acute illness severity (Acute Physiology and Chronic Health Evaluation [APACHE]-II, COPD 15.4±3.5; HF 15.9±3.0), comorbidities (Charlson index, COPD 1.3±1.9; HF 1.6±1.5), and educational background were similar between COPD and HF groups. MoCA total was significantly lower in COPD than in HF (COPD 20.6±5.6; HF 24.8±3.5, P=0.007); however, significance was lost after correction for age, sex, and pack year smoking history. When compared with HF patients, the COPD cohort performed worse on the following domains of the MoCA: visuospatial function (median [IQR], COPD 0 [1]; HF 2 [1], P=0.003), executive function (COPD 2 [1]; HF 3 [1], P=0.035), and attention (COPD 4 [3]; HF 6 [2], P=0.020). Age (P=0.012) and random glucose concentration (P=0.041) were associated with cognitive function in whole group analysis, with pack year smoking history reaching borderline significance (P=0.050). Conclusion: Total MoCA score for COPD and HF indicated that both groups had mild cognitive impairment, although this was greater in people with COPD. Mechanisms underlying the observed cognitive dysfunction in COPD remain unclear but appear related to blood glucose concentrations and greater lifetime smoking load. Keywords: Montreal cognitive assessment, cognition, comorbidities, systemic, smoking, hyperglycemiaBajaj MPKBurrage DRTappouni ADodd JWJones PWBaker EHDove Medical PressarticleMontreal Cognitive AssessmentCognitionComorbiditiesSystemicSmokingHyperglycemiaGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Montreal Cognitive Assessment Cognition Comorbidities Systemic Smoking Hyperglycemia Geriatrics RC952-954.6
spellingShingle	Montreal Cognitive Assessment Cognition Comorbidities Systemic Smoking Hyperglycemia Geriatrics RC952-954.6 Bajaj MPK Burrage DR Tappouni A Dodd JW Jones PW Baker EH COPD patients hospitalized with exacerbations have greater cognitive impairment than patients hospitalized with decompensated heart failure
description	Mohani-Preet K Bajaj,1 Daniel R Burrage,2 Andrew Tappouni,3 James W Dodd,4 Paul W Jones,2 Emma H Baker2 1Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George’s University of London, London, UK; 2Clinical Pharmacology, Institute of Infection and Immunity, St George’s University of London, London, UK; 3St George’s University of London, London, UK; 4Academic Respiratory Unit, University of Bristol, Bristol, UK Purpose: People with COPD have cognitive dysfunction, which is greater in those hospitalized for exacerbations than in stable outpatients. We tested the hypothesis that cognitive dysfunction at exacerbation is a disease-specific feature of COPD, rather than a nonspecific feature of hospitalization for acute illness, by comparing cognition between patients hospitalized for acute COPD exacerbations and those with worsening heart failure (HF). Patients and methods: A total of 40 hospital inpatients were recruited, 20 patients with COPD exacerbations and 20 patients with congestive or left-sided HF. Exclusion criteria included previous stroke, known neurological disease, and marked alcohol excess. Participants completed the Montreal cognitive assessment (MoCA) and Hospital Anxiety and Depression Scale (HADS) and underwent spirometry and review of clinical records. Results: Age (mean±SD, COPD 73±10; HF 76±11 years), acute illness severity (Acute Physiology and Chronic Health Evaluation [APACHE]-II, COPD 15.4±3.5; HF 15.9±3.0), comorbidities (Charlson index, COPD 1.3±1.9; HF 1.6±1.5), and educational background were similar between COPD and HF groups. MoCA total was significantly lower in COPD than in HF (COPD 20.6±5.6; HF 24.8±3.5, P=0.007); however, significance was lost after correction for age, sex, and pack year smoking history. When compared with HF patients, the COPD cohort performed worse on the following domains of the MoCA: visuospatial function (median [IQR], COPD 0 [1]; HF 2 [1], P=0.003), executive function (COPD 2 [1]; HF 3 [1], P=0.035), and attention (COPD 4 [3]; HF 6 [2], P=0.020). Age (P=0.012) and random glucose concentration (P=0.041) were associated with cognitive function in whole group analysis, with pack year smoking history reaching borderline significance (P=0.050). Conclusion: Total MoCA score for COPD and HF indicated that both groups had mild cognitive impairment, although this was greater in people with COPD. Mechanisms underlying the observed cognitive dysfunction in COPD remain unclear but appear related to blood glucose concentrations and greater lifetime smoking load. Keywords: Montreal cognitive assessment, cognition, comorbidities, systemic, smoking, hyperglycemia
format	article
author	Bajaj MPK Burrage DR Tappouni A Dodd JW Jones PW Baker EH
author_facet	Bajaj MPK Burrage DR Tappouni A Dodd JW Jones PW Baker EH
author_sort	Bajaj MPK
title	COPD patients hospitalized with exacerbations have greater cognitive impairment than patients hospitalized with decompensated heart failure
title_short	COPD patients hospitalized with exacerbations have greater cognitive impairment than patients hospitalized with decompensated heart failure
title_full	COPD patients hospitalized with exacerbations have greater cognitive impairment than patients hospitalized with decompensated heart failure
title_fullStr	COPD patients hospitalized with exacerbations have greater cognitive impairment than patients hospitalized with decompensated heart failure
title_full_unstemmed	COPD patients hospitalized with exacerbations have greater cognitive impairment than patients hospitalized with decompensated heart failure
title_sort	copd patients hospitalized with exacerbations have greater cognitive impairment than patients hospitalized with decompensated heart failure
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/6d874a13b9774062bb23263dce6c27fd
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COPD patients hospitalized with exacerbations have greater cognitive impairment than patients hospitalized with decompensated heart failure

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