Discovery of exolytic heparinases and their catalytic mechanism and potential application
Exolytic heparinases are needed for sequencing of heparin and heparan sulfate (HP), but have not yet been reported. Here, the authors identify exolytic heparinases from different bacteria and show that the heparinases preferentially digest HP, determine the crystal structure of the exoheparinase Ble...
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Main Authors: | Qingdong Zhang, Hai-Yan Cao, Lin Wei, Danrong Lu, Min Du, Min Yuan, Deling Shi, Xiangxue Chen, Peng Wang, Xiu-Lan Chen, Lianli Chi, Yu-Zhong Zhang, Fuchuan Li |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
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Subjects: | |
Online Access: | https://doaj.org/article/6d8a8b43feb24d34a0e24a72e67a1fa4 |
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