A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.

Incomplete remyelination is frequent in multiple sclerosis (MS)-lesions, but there is no established marker for recent remyelination. We investigated the role of the oligodendrocyte/myelin protein ermin in de- and remyelination in the cuprizone (CPZ) mouse model, and in MS. The density of ermin+ oli...

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Autores principales:	Intakhar Ahmad, Stig Wergeland, Eystein Oveland, Lars Bø
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6d8b1e73d9f84991a628992635740c45
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spelling	oai:doaj.org-article:6d8b1e73d9f84991a628992635740c452021-12-02T20:17:33ZA higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.1932-620310.1371/journal.pone.0256155https://doaj.org/article/6d8b1e73d9f84991a628992635740c452021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256155https://doaj.org/toc/1932-6203Incomplete remyelination is frequent in multiple sclerosis (MS)-lesions, but there is no established marker for recent remyelination. We investigated the role of the oligodendrocyte/myelin protein ermin in de- and remyelination in the cuprizone (CPZ) mouse model, and in MS. The density of ermin+ oligodendrocytes in the brain was significantly decreased after one week of CPZ exposure (p < 0.02). The relative proportion of ermin+ cells compared to cells positive for the late-stage oligodendrocyte marker Nogo-A increased at the onset of remyelination in the corpus callosum (p < 0.02). The density of ermin-positive cells increased in the corpus callosum during the CPZ-phase of extensive remyelination (p < 0.0001). In MS, the density of ermin+ cells was higher in remyelinated lesion areas compared to non-remyelinated areas both in white- (p < 0.0001) and grey matter (p < 0.0001) and compared to normal-appearing white matter (p < 0.001). Ermin immunopositive cells in MS-lesions were not immunopositive for the early-stage oligodendrocyte markers O4 and O1, but a subpopulation was immunopositive for Nogo-A. The data suggest a relatively higher proportion of ermin immunopositivity in oligodendrocytes compared to Nogo-A indicates recent or ongoing remyelination.Intakhar AhmadStig WergelandEystein OvelandLars BøPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256155 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Intakhar Ahmad Stig Wergeland Eystein Oveland Lars Bø A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
description	Incomplete remyelination is frequent in multiple sclerosis (MS)-lesions, but there is no established marker for recent remyelination. We investigated the role of the oligodendrocyte/myelin protein ermin in de- and remyelination in the cuprizone (CPZ) mouse model, and in MS. The density of ermin+ oligodendrocytes in the brain was significantly decreased after one week of CPZ exposure (p < 0.02). The relative proportion of ermin+ cells compared to cells positive for the late-stage oligodendrocyte marker Nogo-A increased at the onset of remyelination in the corpus callosum (p < 0.02). The density of ermin-positive cells increased in the corpus callosum during the CPZ-phase of extensive remyelination (p < 0.0001). In MS, the density of ermin+ cells was higher in remyelinated lesion areas compared to non-remyelinated areas both in white- (p < 0.0001) and grey matter (p < 0.0001) and compared to normal-appearing white matter (p < 0.001). Ermin immunopositive cells in MS-lesions were not immunopositive for the early-stage oligodendrocyte markers O4 and O1, but a subpopulation was immunopositive for Nogo-A. The data suggest a relatively higher proportion of ermin immunopositivity in oligodendrocytes compared to Nogo-A indicates recent or ongoing remyelination.
format	article
author	Intakhar Ahmad Stig Wergeland Eystein Oveland Lars Bø
author_facet	Intakhar Ahmad Stig Wergeland Eystein Oveland Lars Bø
author_sort	Intakhar Ahmad
title	A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
title_short	A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
title_full	A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
title_fullStr	A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
title_full_unstemmed	A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
title_sort	higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/6d8b1e73d9f84991a628992635740c45
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A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.

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