Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis

Peng Niu,1 Haibo Li,2 Dejun Liu,2 Yan Feng Zhang,1 YongXi Liu,1 Cheng Liang3 1Department of Spine and Joint Surgery, Second General Hospital of Nanyang, Nanyang City, 473009, Henan Province, People’s Republic of China; 2China Department of Orthopaedics, People’s Hospital of Xuecheng, Zaozhuang City,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Niu P, Li H, Liu D, Zhang YF, Liu Y, Liang C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	blood lipid bone mineral density osteoporosis midus ii study Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6d8b5913434a4dd3af636a888cb0c2bc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6d8b5913434a4dd3af636a888cb0c2bc
record_format	dspace
spelling	oai:doaj.org-article:6d8b5913434a4dd3af636a888cb0c2bc2021-11-25T18:55:29ZAssociation Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis1178-7074https://doaj.org/article/6d8b5913434a4dd3af636a888cb0c2bc2021-11-01T00:00:00Zhttps://www.dovepress.com/association-between-hdl-c-and-bone-mineral-density-an-cross-sectional--peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Peng Niu,1 Haibo Li,2 Dejun Liu,2 Yan Feng Zhang,1 YongXi Liu,1 Cheng Liang3 1Department of Spine and Joint Surgery, Second General Hospital of Nanyang, Nanyang City, 473009, Henan Province, People’s Republic of China; 2China Department of Orthopaedics, People’s Hospital of Xuecheng, Zaozhuang City, 277000, Shandong Province, People’s Republic of China; 3The Orthopaedic Center of Joint and Trauma Surgery, The Affiliated Hiser Hospital of Qingdao University, Qingdao City, Shandong Province, 266000, People’s Republic of ChinaCorrespondence: Cheng Liang Tel +86 15589897463Email 593441085@qq.comBackground: Dyslipidemia has been found to contribute to increased risk of osteoporosis and its association with bone mineral density (BMD) remains controversial. We determined whether blood lipid levels are linked with change of BMD.Methods: In a large sample from the MIDUS II study, we sought to evaluate the relationship between blood lipid levels and BMD. Multivariate linear regression models and smooth curve analysis were constructed by controlling a great range of confounding factors.Results: The median age of them was 52.5 years, and the number of males was 176 (40%). Univariate analysis showed that blood high-density lipoprotein-cholesterol (HDL-C) level was negatively related to lunar total femur (r = − 0.266, P < 0.001), lunar radius ultradistal (UD) (r = − 0.297, P < 0.001), lunar radius 1/3 (r = − 0.307, P = 0.001) and femoral neck (r = − 0.172, P = 0.001). In multivariate linear analysis, except for blood triglyceride, total cholesterol and low-density lipoprotein cholesterol (LDL-C), we found that blood HDL-C level was still negatively related to lunar total femur [B = − 0.002, B 95% CI (− 0.002, − 0.001), P < 0.001], lunar radius UD [B = − 0.001, 95% CI (− 0.001, 0), P = 0.002], lunar radius 1/3 [B = − 0.001, 95% CI (− 0.001, 0), P = 0.003] and femoral neck [B = − 0.001, 95% CI (− 0.002, 0), P = 0.039] after adjustments of demographic characteristics, lifestyle, disease history were made. Furthermore, we found that age, sex, and body mass index (BMI) had modifying effects on this negative association.Conclusion: This study confirmed the negative association between HDL-C and BMD in the observational analysis from (MIDUS) study and provides high-quality evidence that age, sex and BMI had modifying effects on this negative association.Keywords: blood lipid, bone mineral density, osteoporosis, MIDUS II studyNiu PLi HLiu DZhang YFLiu YLiang CDove Medical Pressarticleblood lipidbone mineral densityosteoporosismidus ii studyMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8863-8872 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood lipid bone mineral density osteoporosis midus ii study Medicine (General) R5-920
spellingShingle	blood lipid bone mineral density osteoporosis midus ii study Medicine (General) R5-920 Niu P Li H Liu D Zhang YF Liu Y Liang C Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis
description	Peng Niu,1 Haibo Li,2 Dejun Liu,2 Yan Feng Zhang,1 YongXi Liu,1 Cheng Liang3 1Department of Spine and Joint Surgery, Second General Hospital of Nanyang, Nanyang City, 473009, Henan Province, People’s Republic of China; 2China Department of Orthopaedics, People’s Hospital of Xuecheng, Zaozhuang City, 277000, Shandong Province, People’s Republic of China; 3The Orthopaedic Center of Joint and Trauma Surgery, The Affiliated Hiser Hospital of Qingdao University, Qingdao City, Shandong Province, 266000, People’s Republic of ChinaCorrespondence: Cheng Liang Tel +86 15589897463Email 593441085@qq.comBackground: Dyslipidemia has been found to contribute to increased risk of osteoporosis and its association with bone mineral density (BMD) remains controversial. We determined whether blood lipid levels are linked with change of BMD.Methods: In a large sample from the MIDUS II study, we sought to evaluate the relationship between blood lipid levels and BMD. Multivariate linear regression models and smooth curve analysis were constructed by controlling a great range of confounding factors.Results: The median age of them was 52.5 years, and the number of males was 176 (40%). Univariate analysis showed that blood high-density lipoprotein-cholesterol (HDL-C) level was negatively related to lunar total femur (r = − 0.266, P < 0.001), lunar radius ultradistal (UD) (r = − 0.297, P < 0.001), lunar radius 1/3 (r = − 0.307, P = 0.001) and femoral neck (r = − 0.172, P = 0.001). In multivariate linear analysis, except for blood triglyceride, total cholesterol and low-density lipoprotein cholesterol (LDL-C), we found that blood HDL-C level was still negatively related to lunar total femur [B = − 0.002, B 95% CI (− 0.002, − 0.001), P < 0.001], lunar radius UD [B = − 0.001, 95% CI (− 0.001, 0), P = 0.002], lunar radius 1/3 [B = − 0.001, 95% CI (− 0.001, 0), P = 0.003] and femoral neck [B = − 0.001, 95% CI (− 0.002, 0), P = 0.039] after adjustments of demographic characteristics, lifestyle, disease history were made. Furthermore, we found that age, sex, and body mass index (BMI) had modifying effects on this negative association.Conclusion: This study confirmed the negative association between HDL-C and BMD in the observational analysis from (MIDUS) study and provides high-quality evidence that age, sex and BMI had modifying effects on this negative association.Keywords: blood lipid, bone mineral density, osteoporosis, MIDUS II study
format	article
author	Niu P Li H Liu D Zhang YF Liu Y Liang C
author_facet	Niu P Li H Liu D Zhang YF Liu Y Liang C
author_sort	Niu P
title	Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis
title_short	Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis
title_full	Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis
title_fullStr	Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis
title_full_unstemmed	Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis
title_sort	association between hdl-c and bone mineral density: an cross-sectional analysis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/6d8b5913434a4dd3af636a888cb0c2bc
work_keys_str_mv	AT niup associationbetweenhdlcandbonemineraldensityancrosssectionalanalysis AT lih associationbetweenhdlcandbonemineraldensityancrosssectionalanalysis AT liud associationbetweenhdlcandbonemineraldensityancrosssectionalanalysis AT zhangyf associationbetweenhdlcandbonemineraldensityancrosssectionalanalysis AT liuy associationbetweenhdlcandbonemineraldensityancrosssectionalanalysis AT liangc associationbetweenhdlcandbonemineraldensityancrosssectionalanalysis
_version_	1718410529419034624

Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis

Ejemplares similares